This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Editorial

. 2021 Apr 5:7:247-252.

doi: 10.1016/j.xjon.2021.03.022. eCollection 2021 Sep.

Is it time to eliminate the use of opioids in cardiac surgery?

Michael C Grant^{1

2}, Giancarlo Suffredini¹, Brian C Cho¹

Affiliations

Affiliations

¹ Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Md.
² Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Md.

PMID: 36003704
PMCID: PMC9390448
DOI: 10.1016/j.xjon.2021.03.022

Editorial

Is it time to eliminate the use of opioids in cardiac surgery?

Michael C Grant et al. JTCVS Open. 2021.

. 2021 Apr 5:7:247-252.

doi: 10.1016/j.xjon.2021.03.022. eCollection 2021 Sep.

Authors

Michael C Grant^{1

2}, Giancarlo Suffredini¹, Brian C Cho¹

Affiliations

¹ Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Md.
² Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Md.

PMID: 36003704
PMCID: PMC9390448
DOI: 10.1016/j.xjon.2021.03.022

No abstract available

Keywords: Enhanced Recovery After Surgery; multimodal analgesia; nonopioid analgesia; opioids.

PubMed Disclaimer

Figures

None — Rationale, research questions, and central reflection regarding opioids in cardiac surgery.

Figure 1
Reconsideration of the role of opioids in cardiac surgery stems from evidence of their early- and long-term harm as well as our ability to leverage perioperative systems designed to research and implement multimodal analgesic medications and techniques.

See this image and copyright information in PMC

Similar articles

Enhanced Recovery After Surgery and Multimodal Strategies for Analgesia.
Dunkman WJ, Manning MW. Dunkman WJ, et al. Surg Clin North Am. 2018 Dec;98(6):1171-1184. doi: 10.1016/j.suc.2018.07.005. Epub 2018 Aug 22. Surg Clin North Am. 2018. PMID: 30390850 Review.
Multimodal analgesia as an essential part of enhanced recovery protocols in the ambulatory settings.
Kaye AD, Urman RD, Rappaport Y, Siddaiah H, Cornett EM, Belani K, Salinas OJ, Fox CJ. Kaye AD, et al. J Anaesthesiol Clin Pharmacol. 2019 Apr;35(Suppl 1):S40-S45. doi: 10.4103/joacp.JOACP_51_18. J Anaesthesiol Clin Pharmacol. 2019. PMID: 31142958 Free PMC article. Review.
A Multimodal Protocol to Diminish Pain Following Common Orthopedic Sports Procedures: Can We Eliminate Postoperative Opioids?
Moutzouros V, Jildeh TR, Khalil LS, Schwartz K, Hasan L, Matar RN, Okoroha KR. Moutzouros V, et al. Arthroscopy. 2020 Aug;36(8):2249-2257. doi: 10.1016/j.arthro.2020.04.018. Epub 2020 Apr 28. Arthroscopy. 2020. PMID: 32353620
Opioid Versus Nonopioid Analgesia After Carpal Tunnel Release: A Randomized, Prospective Study.
Grandizio LC, Zhang H, Dwyer CL, Goldberg SH, Klena JC. Grandizio LC, et al. Hand (N Y). 2021 Jan;16(1):38-44. doi: 10.1177/1558944719836211. Epub 2019 Mar 29. Hand (N Y). 2021. PMID: 30924372 Free PMC article. Clinical Trial.
Multimodal Nonopioid Pain Protocol Provides Better or Equivalent Pain Control Compared to Opioid Analgesia Following Arthroscopic Rotator Cuff Surgery: A Prospective Randomized Controlled Trial.
Jildeh TR, Abbas MJ, Hasan L, Moutzouros V, Okoroha KR. Jildeh TR, et al. Arthroscopy. 2022 Apr;38(4):1077-1085. doi: 10.1016/j.arthro.2021.11.028. Epub 2021 Nov 25. Arthroscopy. 2022. PMID: 34838987 Clinical Trial.

See all similar articles

Cited by

Commentary: Not so fast….
Dhawan R, Chaney MA. Dhawan R, et al. JTCVS Open. 2021 Jun 15;7:257-258. doi: 10.1016/j.xjon.2021.05.019. eCollection 2021 Sep. JTCVS Open. 2021. PMID: 36003732 Free PMC article. No abstract available.
Commentary: How to kick the opioid habit in cardiac surgery?
Chatterjee S. Chatterjee S. JTCVS Open. 2021 Apr 30;7:255-256. doi: 10.1016/j.xjon.2021.04.015. eCollection 2021 Sep. JTCVS Open. 2021. PMID: 36003691 Free PMC article. No abstract available.
Ketamine as part of multi-modal analgesia may reduce opioid requirements following cardiac surgery: a retrospective observational cohort study.
Hall J, Chung J, Khilkin M, Elkomos-Botros G. Hall J, et al. J Cardiothorac Surg. 2025 Apr 3;20(1):178. doi: 10.1186/s13019-025-03405-x. J Cardiothorac Surg. 2025. PMID: 40181432 Free PMC article.
Can Opioid-Free Anaesthesia Be Personalised? A Narrative Review.
Goff J, Hina M, Malik N, McLardy H, Reilly F, Robertson M, Ruddy L, Willox F, Forget P. Goff J, et al. J Pers Med. 2023 Mar 10;13(3):500. doi: 10.3390/jpm13030500. J Pers Med. 2023. PMID: 36983682 Free PMC article. Review.
A review of recent advances in anesthetic drugs for patients undergoing cardiac surgery.
Sun Y, Sun X, Wu H, Xiao Z, Luo W. Sun Y, et al. Front Pharmacol. 2025 Feb 18;16:1533162. doi: 10.3389/fphar.2025.1533162. eCollection 2025. Front Pharmacol. 2025. PMID: 40041490 Free PMC article. Review.

See all "Cited by" articles

References

1. Lowenstein E., Hallowell P., Levine F.H., Daggett W.M., Austen W.G., Laver M.B. Cardiovascular response to large doses of intravenous morphine in man. N Engl J Med. 1969;281:1389–1393. - PubMed
1. Skubas N.J., Lichtman A.D., Wang C.J. In: Clinical Anesthesia. 8th ed. Paul G., Barash P.G., Cullen B.F., Stoelting R.K., Stock M.C., Stoelting R.K., Ortega R., et al., editors. Walters Kluwer; Philadelphia: 2017. Anesthesia for cardiac surgery. 1077-11.
1. Silbert B.S., Scott D.A., Evered L.A., Lewis M.S., Kalpokas M., Maruff P., et al. A comparison of the effect of high- and low-dose fentanyl on the incidence of postoperative cognitive dysfunction after coronary artery bypass surgery in the elderly. Anesthesiology. 2006;104:1137–1145. - PubMed
1. Dasinger E.A., Branch-Elliman W., Pizer S.D., Abdulkerim H., Rosen A.K., Charns M.P., et al. Association between postoperative opioid use and outpatient surgical adverse events. Am J Surg. 2019;217:605–612. - PMC - PubMed
1. Myles P.S., Daly D.J., Djaiani G., Lee A., Cheng D.C. A systematic review of the safety and effectiveness of fast-track cardiac anesthesia. Anesthesiology. 2003;99:982–987. - PubMed

Publication types

Actions

LinkOut - more resources

Full Text Sources