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. 2022 Aug 18:18:643-652.
doi: 10.2147/VHRM.S376955. eCollection 2022.

Risk Factors for Calcific Aortic Valve Disease in Afghan Population

Abdul Ghafar Sherzad  1   2 , Muhibullah Shinwari  3 , M Azim Azimee  2 , Arash Nemat  1   4 , Qingchun Zeng  1   5
Affiliations

Risk Factors for Calcific Aortic Valve Disease in Afghan Population

Abdul Ghafar Sherzad et al. Vasc Health Risk Manag. .

Abstract

Objective: Evidence from previous studies suggests that calcific aortic valve disease (CAVD) is not an unavoidable consequence of aging, and may be linked to explicit risk factors. However, little is known regarding the Afghan population in this context. The current study aimed to identify the clinical features of CAVD and determine independent risk factors for CAVD in the Afghan population.

Patients and methods: A case-control study was conducted among 1072 Afghan participants (age >18 years) from January 2018 to December 2020. The study participants were divided into two groups based on echocardiographic findings: 536 individuals with CAVD and 536 age- and sex-matched controls. Data were collected using questionnaires from the medical records of all cases and controls. The independent predictors of CAVD were evaluated using multivariate logistic regression analysis.

Results: The mean age of study participants was 65.3 ± 13.5 years (range, 20-100 years). Of the 536 patients with CAVD, 77 (14.4%) had aortic valve stenosis, 415 (77.4%) had aortic valve calcification, and 44 (8.2%) had bicuspid aortic valve. Multivariate logistic regression analysis revealed that sedentary lifestyle (odds ratio [OR] = 2.517, p = 003), diabetes mellitus (DM) (OR = 1.902, p = 006), high body mass index (BMI ≥ 30 kg/m2) (OR = 1.776, p = 005), good socioeconomic status (OR = 1.724, p = 021), and hypertension (OR = 1.664, p ˂0.001) were independent risk factors for CAVD in the Afghan population.

Conclusion: It was observed that sedentary lifestyle, diabetes mellitus, high BMI (≥ 30 kg/m2), good socioeconomic status, and hypertension are independent risk factors for the development of CAVD compared to those with a normal aortic valve in the Afghan population.

Keywords: aortic valve calcification; aortic valve sclerosis; aortic valve stenosis; independent risk factors; risk factors for atherosclerosis.

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Conflict of interest statement

The authors declare that they have no conflicts of interest in relation to this work.

References

    1. Rajamannan NM, Evans FJ, Aikawa E, et al. Calcific aortic valve disease: not simply a degenerative process a review and agenda for research from the national heart and lung and blood institute aortic stenosis working group. Circulation. 2011;124(16):1783. doi: 10.1161/CIRCULATIONAHA.110.006767 - DOI - PMC - PubMed
    1. Otto CM, Lind BK, Kitzman DW, Gersh BJ, Siscovick DS. Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly. N Engl J Med. 1999;341(3):142–147. doi: 10.1056/NEJM199907153410302 - DOI - PubMed
    1. Yi B, Zeng W, Lv L, Hua P. Changing epidemiology of calcific aortic valve disease: 30-year trends of incidence, prevalence, and deaths across 204 countries and territories. Aging. 2021;13(9):12710–12732. doi: 10.18632/aging.202942 - DOI - PMC - PubMed
    1. Scatena M, Jackson MF, Speer MY, Leaf EM, Wallingford MC, Giachelli CM. Increased calcific aortic valve disease in response to a diabetogenic, procalcific diet in the LDLr-/-ApoB100/100 mouse model. Cardiovasc Pathol. 2018;34:28–37. doi: 10.1016/j.carpath.2018.02.002 - DOI - PMC - PubMed
    1. Iung B, Vahanian A. Degenerative calcific aortic stenosis: a natural history. Heart. 2012;98(Suppl4):iv7–iv13. doi: 10.1136/heartjnl-2012-302395 - DOI - PubMed

Supplementary concepts