Understanding the Pivotal Role of the Vagus Nerve in Health from Pandemics

doi:10.3390/bioengineering9080352

. 2022 Jul 29;9(8):352.

doi: 10.3390/bioengineering9080352.

Understanding the Pivotal Role of the Vagus Nerve in Health from Pandemics

Claire-Marie Rangon¹, Adam Niezgoda²

Affiliations

¹ Child Neurologist and Pain Specialist, INWE'CARE Medical Center, 92210 Saint-Cloud, France.
² Chair and Department of Neurology, University of Medical Sciences, 60-355 Poznań, Poland.

PMID: 36004877
PMCID: PMC9405360
DOI: 10.3390/bioengineering9080352

Understanding the Pivotal Role of the Vagus Nerve in Health from Pandemics

Claire-Marie Rangon et al. Bioengineering (Basel). 2022.

. 2022 Jul 29;9(8):352.

doi: 10.3390/bioengineering9080352.

Authors

Claire-Marie Rangon¹, Adam Niezgoda²

Affiliations

¹ Child Neurologist and Pain Specialist, INWE'CARE Medical Center, 92210 Saint-Cloud, France.
² Chair and Department of Neurology, University of Medical Sciences, 60-355 Poznań, Poland.

PMID: 36004877
PMCID: PMC9405360
DOI: 10.3390/bioengineering9080352

Abstract

The COVID-19 pandemic seems endless with the regular emergence of new variants. Is the SARS-CoV-2 virus particularly evasive to the immune system, or is it merely disrupting communication between the body and the brain, thus pre-empting homeostasis? Retrospective analysis of the COVID-19 and AIDS pandemics, as well as prion disease, emphasizes the pivotal but little-known role of the 10th cranial nerve in health. Considering neuroimmunometabolism from the point of view of the vagus nerve, non-invasive bioengineering solutions aiming at monitoring and stimulating the vagal tone are subsequently discussed as the next optimal and global preventive treatments, far beyond pandemics.

Keywords: COVID-19; HIV; neuroimmunometabolism; non-invasive vagus nerve stimulation; pandemics; prion.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

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[1] Izda V., Jeffries M.A., Sawalha A.H. COVID-19: A Review of Therapeutic Strategies and Vaccine Candidates. Clin. Immunol. 2021;222:108634. doi: 10.1016/j.clim.2020.108634. - DOI - PMC - PubMed

[2] Izda V., Jeffries M.A., Sawalha A.H. COVID-19: A Review of Therapeutic Strategies and Vaccine Candidates. Clin. Immunol. 2021;222:108634. doi: 10.1016/j.clim.2020.108634. - DOI - PMC - PubMed

[3] Priyadarsini S.L., Suresh M., Huisingh D. What Can We Learn from Previous Pandemics to Reduce the Frequency of Emerging Infectious Diseases like COVID-19? Glob. Transit. 2020;2:202–220. doi: 10.1016/j.glt.2020.09.003. - DOI - PMC - PubMed

[4] Priyadarsini S.L., Suresh M., Huisingh D. What Can We Learn from Previous Pandemics to Reduce the Frequency of Emerging Infectious Diseases like COVID-19? Glob. Transit. 2020;2:202–220. doi: 10.1016/j.glt.2020.09.003. - DOI - PMC - PubMed

[5] Lopes Fischer N., Naseer N., Shin S., Brodsky I.E. Effector-Triggered Immunity and Pathogen Sensing in Metazoans. Nat. Microbiol. 2020;5:14–26. doi: 10.1038/s41564-019-0623-2. - DOI - PMC - PubMed

[6] Lopes Fischer N., Naseer N., Shin S., Brodsky I.E. Effector-Triggered Immunity and Pathogen Sensing in Metazoans. Nat. Microbiol. 2020;5:14–26. doi: 10.1038/s41564-019-0623-2. - DOI - PMC - PubMed

[7] Hoffman C., Aballay A. Role of Neurons in the Control of Immune Defense. Curr. Opin. Immunol. 2019;60:30–36. doi: 10.1016/j.coi.2019.04.005. - DOI - PMC - PubMed

[8] Hoffman C., Aballay A. Role of Neurons in the Control of Immune Defense. Curr. Opin. Immunol. 2019;60:30–36. doi: 10.1016/j.coi.2019.04.005. - DOI - PMC - PubMed

[9] Pavlov V.A., Tracey K.J. The Vagus Nerve and the Inflammatory Reflex—Linking Immunity and Metabolism. Nat. Rev. Endocrinol. 2012;8:743–754. doi: 10.1038/nrendo.2012.189. - DOI - PMC - PubMed

[10] Pavlov V.A., Tracey K.J. The Vagus Nerve and the Inflammatory Reflex—Linking Immunity and Metabolism. Nat. Rev. Endocrinol. 2012;8:743–754. doi: 10.1038/nrendo.2012.189. - DOI - PMC - PubMed

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Understanding the Pivotal Role of the Vagus Nerve in Health from Pandemics

Affiliations

Understanding the Pivotal Role of the Vagus Nerve in Health from Pandemics

Authors

Affiliations

Abstract

Conflict of interest statement

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