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. 2022 Aug 9;90(4):312-322.
doi: 10.3390/arm90040041.

Prognostic Value of Chest-Computed Tomography in Patients with COVID-19

Gökhan Perincek  1 , Canver Önal  2 , Timor Omar  3
Affiliations

Prognostic Value of Chest-Computed Tomography in Patients with COVID-19

Gökhan Perincek et al. Adv Respir Med. .

Abstract

Background: The diagnostic value for chest CT has been widely established in patients with COVID-19. However, there is a lack of satisfactory data about the prognostic value of chest CTs. This study investigated the prognostic value of chest CTs in COVID-19 patients. Materials and Methods: A total of 521 symptomatic patients hospitalized with COVID-19 were included retrospectively. Clinical, laboratory, and chest CT characteristics were compared between survivors and non-survivors. Concerning chest CT, for each subject, a semi-quantitative CT severity scoring system was applied. Results: Most patients showed typical CT features based on the likelihood of COVID-19. The global CT score was significantly higher in non-survivors (median (IQR), 1 (0−6) vs. 10 (5−13), p < 0.001). A cut-off value of 5.5 for the global CT score predicted in-hospital mortality with 74% sensitivity and 73% specificity. Global CT score, age, C-reactive protein, and diabetes were independent predictors of in-hospital mortality. The global CT score was significantly correlated with the C-reactive protein, D-dimer, pro-brain natriuretic peptide, and procalcitonin levels. Conclusion: The global CT score could provide valuable prognostic data in symptomatic patients with COVID-19.

Keywords: COVID-19; chest CT; computed tomography; mortality; prognosis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chest CT findings of COVID-19 showthe CT score of right lower lobe involvement on axial, sagittal, and coronal images. (A) Score 0, 0% involvement; (B) Score 1, <5% involvement; (C) Score 2, 5–25% involvement; (D) Score 3, 26–49% involvement; (E) Score 4, 50–75% involvement; (F) Score 5, >75% involvement. CT: Computed tomography.
Figure 2
Figure 2
Chest CT findings of COVID-19. Transaxial images show (A) Bilateral, peripheral GGO; (B) Bilateral consolidation; (C) Multifocal rounded GGO. CT: computed tomography, GGO: ground-glass opacity.
Figure 3
Figure 3
Diagnostic accuracy of the global CT score on in-hospital mortality in symptomatic patients with COVID-19 by the ROC curve.
Figure 4
Figure 4
Correlation graphics between global CT score and C-reactive protein (A), global CT score and D-dimer (B), global CT score and pro-BNP (C), and global CT score and procalcitonin (D).
See this image and copyright information in PMC

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