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Review
. 2022 Aug 5;12(8):726.
doi: 10.3390/metabo12080726.

Blood and Urinary Biomarkers of Antipsychotic-Induced Metabolic Syndrome

Aiperi K Khasanova  1 , Vera S Dobrodeeva  1 , Natalia A Shnayder  1   2 , Marina M Petrova  2 , Elena A Pronina  2 , Elena N Bochanova  2 , Natalia V Lareva  3 , Natalia P Garganeeva  4 , Daria A Smirnova  5 , Regina F Nasyrova  1   5
Affiliations
Review

Blood and Urinary Biomarkers of Antipsychotic-Induced Metabolic Syndrome

Aiperi K Khasanova et al. Metabolites. .

Abstract

Metabolic syndrome (MetS) is a clustering of at least three of the following five medical conditions: abdominal obesity, high blood pressure, high blood sugar, high serum triglycerides, and low serum high-density lipoprotein (HDL). Antipsychotic (AP)-induced MetS (AIMetS) is the most common adverse drug reaction (ADR) of psychiatric pharmacotherapy. Herein, we review the results of studies of blood (serum and plasma) and urinary biomarkers as predictors of AIMetS in patients with schizophrenia (Sch). We reviewed 1440 studies examining 38 blood and 19 urinary metabolic biomarkers, including urinary indicators involved in the development of AIMetS. Among the results, only positive associations were revealed. However, at present, it should be recognized that there is no consensus on the role of any particular urinary biomarker of AIMetS. Evaluation of urinary biomarkers of the development of MetS and AIMetS, as one of the most common concomitant pathological conditions in the treatment of patients with psychiatric disorders, may provide a key to the development of strategies for personalized prevention and treatment of the condition, which is considered a complication of AP therapy for Sch in clinical practice.

Keywords: antipsychotic-induced metabolic syndrome; antipsychotics; metabolic syndrome; personalized metabolomics; personalized psychiatry; serum biomarkers; urinary biomarkers.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Potential Blood (Serum and Plasma) and Urinary Biomarkers of Antipsychotics—Induced Metabolic Syndrome (AIMetS) in Patients with Schizophrenia (Sch).
Figure 2
Figure 2
Potential Blood (Serum and Plasma) and Urinary Biomarkers of Antipsychotics—Induced Metabolic Syndrome (AIMetS) in Patients with Schizophrenia (Sch).
Figure 3
Figure 3
Algorithm of Personalized Approach to the Diagnosis of Antipsychotics—Induced Metabolic Syndrome (AIMetS) in Patients with Schizophrenia (Sch) Based on Blood and Urinary Biomarkers: Definite, Probable and Possible AIMetS.
See this image and copyright information in PMC

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