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. 2022 Nov;21(11):6428-6433.
doi: 10.1111/jocd.15329. Epub 2022 Sep 20.

Unraveling the relation between vitiligo, Interleukin 17, and serum amyloid A

Aliaa Abd Elsalam Ahmed  1 , Nancy Wadie Mikhael  1 , Asmaa Adel Elfallah  2 , Ahmed Mohammed Hamed  1
Affiliations

Unraveling the relation between vitiligo, Interleukin 17, and serum amyloid A

Aliaa Abd Elsalam Ahmed et al. J Cosmet Dermatol. 2022 Nov.

Abstract

Background: There is debate concerning the precise etiopathogenesis of vitiligo. According to certain theories, a series of inflammatory responses that mediate the loss of melanocytes are caused by both cellular and humoral immune responses. It has also been demonstrated that Interleukin 17 (IL-17) promotes melanocyte death and inhibits melanogenesis through different mechanisms. Serum Amyloid A (SAA) levels are over-expressed in autoimmune diseases. Th17 cytokines are regulated by serum amyloid A proteins.

Aims: To measure serum levels of IL-17 and SAA in vitiligo patients aiming to explain their possible role in disease pathogenesis and the other aim is to correlate their levels with disease activity and severity.

Methods: This study included 60 vitiligo patients and 40 healthy age and sex controls. Enzyme-linked immunosorbent assay was used to measure serum levels of SAA and IL-17.

Results: This study revealed significant increase in levels of serum IL-17 and SAA in patients than controls (p < 0.05). Both markers showed significant positive correlations with VASI score and duration of vitiligo; only IL-17 showed statistically significant positive correlation with VIDA scores. Patients with vitiligo showed a statistically significant positive connection between serum IL-17 levels and SAA (γ = 0.992, p-value <0.05).

Conclusion: Increased serum level of IL-17 and SAA in vitiligo patients together with their positive relation to vitiligo severity and the duration of the disease show that these two markers play a key role in the vitiligo development.

Keywords: Interleukin-17; serum amyloid A; vitiligo.

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References

REFERENCES

    1. Mikhael NW, Sabry HH, El-Refaey AM, Salem RM, El-Gendy MF, Farid SA. Clinimetric analysis of recently applied quantitative tools in evaluation of vitiligo treatment. Indian J Dermatol Venereol Leprol. 2019;85:466-474.
    1. Cui T, Zhang W, Li S, et al. Oxidative stress-induced HMGB1 release from melanocytes: a paracrine mechanism underlying the cutaneous inflammation in vitiligo. Invest Dermatol. 2019;139(10):2174-2184.
    1. Basak PY, Adiloglu AK, Ceyhan AM, Tas T, Akkaya VB. The role of helper and regulatory T cells in the pathogenesis of vitiligo. J Am Acad Dermatol. 2009;60(2):256-260.
    1. Kotobuki Y, Tanemura A, Yang L, et al. Dysregulation of melanocyte function by Th17-related cytokines: significance of Th17 cell infiltration in autoimmune vitiligo vulgaris. Pigment Cell Melanoma Res. 2012;25:219-230.
    1. Lloyd-Price J, Arze C, Ananthakrishnan AN, et al. Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases. Nature. 2019;569:655-662.

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