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Review
. 2022 Jul 27;7(8):150.
doi: 10.3390/tropicalmed7080150.

Fibrinogen-to-Albumin Ratio and Blood Urea Nitrogen-to-Albumin Ratio in COVID-19 Patients: A Systematic Review and Meta-Analysis

Juan R Ulloque-Badaracco  1   2 , Esteban A Alarcon-Braga  1   2 , Enrique A Hernandez-Bustamante  3   4 , Ali Al-Kassab-Córdova  1 , Melany D Mosquera-Rojas  1   2 , Ricardo R Ulloque-Badaracco  5 , Miguel A Huayta-Cortez  1 , Sherelym H Maita-Arauco  1 , Percy Herrera-Añazco  6   7 , Vicente A Benites-Zapata  8
Affiliations
Review

Fibrinogen-to-Albumin Ratio and Blood Urea Nitrogen-to-Albumin Ratio in COVID-19 Patients: A Systematic Review and Meta-Analysis

Juan R Ulloque-Badaracco et al. Trop Med Infect Dis. .

Abstract

Fibrinogen-to-albumin ratio (FAR) and blood urea nitrogen-to-albumin ratio (BAR) are inflammatory biomarkers that have been associated with clinical outcomes of multiple diseases. The objective of this study is to evaluate the association of these biomarkers with the severity and mortality of COVID-19 patients. A systematic search was performed in five databases. Observational studies that reported the association between FAR and BAR values with the severity and mortality of COVID-19 patients were included. Random-effects models were used for meta-analyses, and effects were expressed as Odds Ratio (OR) and their 95% confidence intervals (CI). Publication bias was assessed using the Begg test, while the quality assessment was assessed using the Newcastle Ottawa Scale. A total of 21 studies (n = 7949) were included. High FAR values were associated with a higher risk of severity (OR: 2.41; 95% CI 1.41−4.12; p < 0.001) and mortality (OR: 2.05; 95% CI 1.66−2.54; p < 0.001). High BAR values were associated with higher risk of mortality (OR: 4.63; 95% CI 2.11−10.15; p < 0.001). However, no statistically significant association was found between BAR values and the risk of severity (OR: 1.16; 95% CI 0.83−1.63; p = 0.38). High FAR and BAR values were associated with poor clinical outcomes.

Keywords: COVID-19; albumin; blood urea nitrogen; fibrinogen; urea.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA Flow Diagram.
Figure 2
Figure 2
Association between FAR and severity of COVID-19 patients [33,34,36,39,40,41,50,52].
Figure 3
Figure 3
Association between FAR and mortality of COVID-19 patients [34,35,37,38,40,41,42,43,52].
Figure 4
Figure 4
Association between BAR and severity of COVID-19 patients [33,44,45,49].
Figure 5
Figure 5
Association between BAR and mortality of COVID-19 patients [46,47,48,49,51].
See this image and copyright information in PMC

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