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Case Reports
. 2022 Aug 1;9(8):402.
doi: 10.3390/vetsci9080402.

Ovarian Neuroglial Choristoma in a Bitch

Eleonora Brambilla  1 , Barbara Banco  2 , Stefano Faverzani  1 , Paola Scarpa  1 , Alessandro Pecile  1 , Debora Groppetti  1 , Claudio Pigoli  3 , Marco Giraldi  2 , Valeria Grieco  1
Affiliations
Case Reports

Ovarian Neuroglial Choristoma in a Bitch

Eleonora Brambilla et al. Vet Sci. .

Abstract

Neuroglial choristomas are rare malformations consisting of heterotopic mature neural tissue at a site isolated from the brain or spinal cord. In human medicine, neuroglial choristomas are predominantly reported in the head and in the neck, except for one recent case reported in a foot of a child. In domestic animals, neuroglial choristomas are exceedingly rare, reported only in the retina of a dog, in the pharynx and in the skin of two kittens, and within the oropharynx of a harbor seal. A three-year-old intact female Jack Russell Terrier presented for elective ovariectomy exhibited a cystic lesion 2 cm in diameter expanding in the right ovary. Histological examination of the lesion revealed a mass composed of well-organized neuroglial tissue. Immunohistochemistry with primary antibodies against GFAP, NSE, and IBA-1 confirmed the neuroglial origin of the mass. At the time of this writing, 7 years after ovariectomy, the dog was clinically normal. Together with a recent case described in the foot of a child, this case confirms that neuroglial choristoma may also be found far from the skull or spine, supporting the hypothesis that they may arise from an early embryological migration defect.

Keywords: choristoma; dog; neuroglial choristoma; ovarian choristoma; ovary.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
(a) Well-organized neuroglial tissue facing an optically empty cystic cavity internally lined by ependymal tissue organized to form a choroid plexus; H&E; 200×. (b) GFAP strongly and diffusely labels the fibrillary background and glial cell cytoplasm and branches (inset); IHC; 400×, inset 1000×. (c) NSE strongly labels the neuronal cytoplasm (arrows) and neuropil; IHC; 400×. (d) IBA-1 strongly labels microglial cell cytoplasm and cytoplasmatic branching processes; IHC; 400×.
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