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. 2022 Oct;32(10):6800-6811.
doi: 10.1007/s00330-022-09079-6. Epub 2022 Aug 25.

Air embolism in CT-guided transthoracic needle biopsy: emphasis on pulmonary vein injury

Yura Ahn  1 , Sang Min Lee  2 , Hwa Jung Kim  3 , Jooae Choe  1 , Sang Young Oh  1 , Kyung-Hyun Do  1 , Joon Beom Seo  1
Affiliations

Air embolism in CT-guided transthoracic needle biopsy: emphasis on pulmonary vein injury

Yura Ahn et al. Eur Radiol. 2022 Oct.

Abstract

Objective: To assess whether pulmonary vein injury is detectable on CT and associated with air embolism after percutaneous transthoracic needle biopsy (PTNB) in a tertiary referral hospital.

Methods: Between January 2012 and November 2021, 11,691 consecutive CT-guided PTNBs in 10,685 patients were retrospectively evaluated. Air embolism was identified by reviewing radiologic reports. Pulmonary vein injury was defined as the presence of the pulmonary vein in the needle pathway or shooting range of the cutting needle with the presence of parenchymal hemorrhage. The association between pulmonary vein injury and air embolism was assessed using logistic regression analysis in matched patients with and without air embolism with a ratio of 1:4.

Results: A total of 27 cases of air embolism (median age, 67 years; range, 48-80 years; 24 men) were found with an incidence of 0.23% (27/11,691). Pulmonary vein injury during the procedures was identifiable on CT in 24 of 27 patients (88.9%), whereas it was 1.9% (2/108) for matched patients without air embolism The veins beyond the target lesion (70.8% [17/24]) were injured more frequently than the veins in the needle pathway before the target lesion (29.2% [7/24]). In univariable and multivariable analyses, pulmonary vein injury was associated with air embolism (odds ratio, 485.19; 95% confidence interval, 68.67-3428.19, p <.001).

Conclusion: Pulmonary vein injury was detected on CT and was associated with air embolism. Avoiding pulmonary vein injury with careful planning of the needle pathway on CT may reduce air embolism risk.

Key points: • Pulmonary vein injury during CT-guided biopsy was identifiable on CT in most of the patients (88.9% [24/27]). • The veins beyond the target lesion (70.8% [17/24]) were injured more frequently than the veins in the needle pathway before the target lesion (29.2% [7/24]). • Avoiding the distinguishable pulmonary vein along the pathway or shooting range of the needle on CT may reduce the air embolism risk.

Keywords: Air; Computed tomography, X-ray; Embolism; Image-guided biopsy; Lung neoplasms.

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References

    1. Hiraki T, Mimura H, Gobara H et al (2009) CT fluoroscopy-guided biopsy of 1,000 pulmonary lesions performed with 20-gauge coaxial cutting needles: diagnostic yield and risk factors for diagnostic failure. Chest 136:1612–1617 - DOI
    1. Lee KH, Lim KY, Suh YJ et al (2019) Diagnostic accuracy of percutaneous transthoracic needle lung biopsies: a multicenter study. Korean J Radiol 20:1300–1310 - DOI
    1. Cho J, Ko SJ, Kim SJ et al (2014) Surgical resection of nodular ground-glass opacities without percutaneous needle aspiration or biopsy. BMC Cancer 14:838 - DOI
    1. Heerink WJ, de Bock GH, de Jonge GJ, Groen HJ, Vliegenthart R, Oudkerk M (2017) Complication rates of CT-guided transthoracic lung biopsy: meta-analysis. Eur Radiol 27:138–148 - DOI
    1. Freund MC, Petersen J, Goder KC, Bunse T, Wiedermann F, Glodny B (2012) Systemic air embolism during percutaneous core needle biopsy of the lung: frequency and risk factors. BMC Pulm Med 12:2 - DOI

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