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. 2022 Oct;48(10):1322-1325.
doi: 10.1007/s00134-022-06827-6. Epub 2022 Aug 25.

Physiology of extracorporeal CO2 removal

Luciano Gattinoni  1 , Silvia Coppola  2 , Luigi Camporota  3
Affiliations

Physiology of extracorporeal CO2 removal

Luciano Gattinoni et al. Intensive Care Med. 2022 Oct.
No abstract available

PubMed Disclaimer

Conflict of interest statement

LG reports a consultancy for General Electrics and SIDAM. He also receives lecture fees from Estor and Mindray.

Figures

Fig. 1
Fig. 1
Physiology of ECCO2R: The amount of CO2 removed (VCO2) by the membrane lung is proportional to the gas-flow, the logarithm of extra-corporeal blood-flow; the pre-membrane PCO2 and the membrane lung surface. The sum of the VCO2 of the membrane and the natural lungs, at equilibrium, equals the metabolic VCO2. A reduction in the VCO2 of the natural lung decreases the respiratory quotient (RQ) and, therefore, alveolar PO2 (PAO2). The alveolar nitrogen may decrease if the membrane lung is ventilated with fractions of oxygen higher than those delivered to the natural lung. The decrease of VCO2 of the natural lung allows the decrease in tidal volume and mean airways pressure, which can promote lung collapse
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References

    1. Kolobow T, Gattinoni L, Tomlinson TA, Pierce JE. Control of breathing using an extracorporeal membrane lung. Anesthesiology. 1977;46:138–141. doi: 10.1097/00000542-197702000-00012. - DOI - PubMed
    1. Gattinoni L, Agostoni A, Pesenti A, Pelizzola A, Rossi GP, Langer M, Vesconi S, Uziel L, Fox U, Longoni F, Kolobow T, Damia G. Treatment of acute respiratory failure with low-frequency positive-pressure ventilation and extracorporeal removal of CO2. Lancet (London, England) 1980;2:292–294. doi: 10.1016/s0140-6736(80)90237-8. - DOI - PubMed
    1. Combes A, Fanelli V, Pham T, Ranieri VM. Feasibility and safety of extracorporeal CO(2) removal to enhance protective ventilation in acute respiratory distress syndrome: the SUPERNOVA study. Intensive Care Med. 2019;45:592–600. doi: 10.1007/s00134-019-05567-4. - DOI - PubMed
    1. McNamee JJ, Gillies MA, Barrett NA, Perkins GD, Tunnicliffe W, Young D, Bentley A, Harrison DA, Brodie D, Boyle AJ, Millar JE, Szakmany T, Bannard-Smith J, Tully RP, Agus A, McDowell C, Jackson C, McAuley DF. Effect of lower tidal volume ventilation facilitated by extracorporeal carbon dioxide removal vs standard care ventilation on 90-day mortality in patients with acute hypoxemic respiratory failure: the REST randomized clinical trial. JAMA. 2021;326:1013–1023. doi: 10.1001/jama.2021.13374. - DOI - PMC - PubMed
    1. Kolobow T, Gattinoni L, Tomlinson T, White D, Pierce J, Iapichino G. The carbon dioxide membrane lung (CDML): a new concept. Transactions. 1977;23:17–21. doi: 10.1097/00002480-197700230-00005. - DOI - PubMed

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