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. 2022 Dec;81(10):881-887.
doi: 10.1007/s00393-022-01260-y. Epub 2022 Aug 25.

[The role of the response to DNA damage in granulomatous diseases]

[Article in German]
Lea A R Fabry  1   2 , Antigoni Triantafyllopoulou  3   4
Affiliations

[The role of the response to DNA damage in granulomatous diseases]

[Article in German]
Lea A R Fabry et al. Z Rheumatol. 2022 Dec.

Abstract
in English, German

Granulomas are organized aggregates of immune cells, which are formed in response to a persistent stimulus and are found in various rheumatic diseases, including sarcoidosis, rheumatoid arthritis and granulomatosis with polyangiitis. The core of granulomas contains a multitude of different macrophage subtypes, including multinucleated macrophages and foam cells. The mechanisms which induce the formation of granulomas are not well understood; however, recent data show that the DNA damage response regulates granuloma macrophage differentiation.

Granulome sind organisierte Aggregate von Immunzellen, die sich infolge eines persistierenden Stimulus bilden und bei verschiedenen rheumatischen Erkrankungen zu finden sind. Zentraler Bestandteil von Granulomen ist eine Vielzahl unterschiedlicher Makrophagensubtypen. Darunter befinden sich auch multinukleäre Makrophagen, die mehrere Zellkerne aufweisen. Die genauen Mechanismen, welche die Granulomentstehung vermitteln, sind bislang noch nicht vollständig aufgeklärt. Neuere Daten zeigen jedoch, dass die DNA-Schadensantwort eine relevante Rolle bei der Entstehung multinukleärer Makrophagen und damit bei der Bildung von Granulomen spielen könnte.

Keywords: DNA damage response; Genotoxic stress; Granulomas; Multinucleated macrophages; Sarcoidosis.

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