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. 1987 May;7(5):1967-72.
doi: 10.1128/mcb.7.5.1967-1972.1987.

Chromatin structure of the HLA-DR alpha gene in different functional states of major histocompatibility complex class II gene expression

B M Peterlin, K J Hardy, A S Larsen

Chromatin structure of the HLA-DR alpha gene in different functional states of major histocompatibility complex class II gene expression

B M Peterlin et al. Mol Cell Biol. 1987 May.

Abstract

We utilized DNase I hypersensitivity mapping to study chromatin structure within the HLA-DR alpha gene. We found a single DNase I-hypersensitive site coinciding with the HLA-DR alpha gene promoter in all cells studied. Moreover, in cells that constitutively express HLA-DR, two additional DNase I-hypersensitive sites were observed. These lie within the first intron of the HLA-DR alpha gene and encompass DNA sequences that share homologies with regulatory loci of the immunoglobulin and immune response genes, as well as with core enhancer consensus sequences.

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References

    1. Intervirology. 1975;5(6):319-34 - PubMed
    1. J Mol Cell Immunol. 1984;1(3):191-200 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 May;75(5):2458-62 - PubMed
    1. Biochemistry. 1979 Nov 27;18(24):5294-9 - PubMed
    1. Blood. 1980 Mar;55(3):409-17 - PubMed

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