Comparative analysis of transmission and vaccine effectiveness in Omicron and Delta variant outbreaks in China

doi:10.1016/j.jinf.2022.08.018

. 2023 Jan;86(1):66-117.

doi: 10.1016/j.jinf.2022.08.018. Epub 2022 Aug 22.

Comparative analysis of transmission and vaccine effectiveness in Omicron and Delta variant outbreaks in China

Kangguo Li¹, Feng Ruan², Zeyu Zhao³, Zhinan Guo⁴, Zimei Yang¹, Shanshan Yu¹, Buasiyamu Abudunaibi¹, Xuebao Zhang², Xiling Yin², Wenhua Mei⁵, Tianmu Chen⁶

Affiliations

¹ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Fujian, China.
² Zhuhai Center for Disease Control and Prevention, Guangdong, China.
³ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Fujian, China; CIRAD, Intertryp, Montpellier, France, IES, Université de Montpellier-CNRS, Montpellier, France.
⁴ Xiamen Center for Disease Control and Prevention, Fujian, China.
⁵ Zhuhai Center for Disease Control and Prevention, Guangdong, China. Electronic address: 1297648405@qq.com.
⁶ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Fujian, China. Electronic address: 13698665@qq.com.

PMID: 36007658
PMCID: PMC9394093
DOI: 10.1016/j.jinf.2022.08.018

Comparative analysis of transmission and vaccine effectiveness in Omicron and Delta variant outbreaks in China

Kangguo Li et al. J Infect. 2023 Jan.

. 2023 Jan;86(1):66-117.

doi: 10.1016/j.jinf.2022.08.018. Epub 2022 Aug 22.

Authors

Kangguo Li¹, Feng Ruan², Zeyu Zhao³, Zhinan Guo⁴, Zimei Yang¹, Shanshan Yu¹, Buasiyamu Abudunaibi¹, Xuebao Zhang², Xiling Yin², Wenhua Mei⁵, Tianmu Chen⁶

Affiliations

¹ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Fujian, China.
² Zhuhai Center for Disease Control and Prevention, Guangdong, China.
³ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Fujian, China; CIRAD, Intertryp, Montpellier, France, IES, Université de Montpellier-CNRS, Montpellier, France.
⁴ Xiamen Center for Disease Control and Prevention, Fujian, China.
⁵ Zhuhai Center for Disease Control and Prevention, Guangdong, China. Electronic address: 1297648405@qq.com.
⁶ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Fujian, China. Electronic address: 13698665@qq.com.

PMID: 36007658
PMCID: PMC9394093
DOI: 10.1016/j.jinf.2022.08.018

No abstract available

Keywords: COVID-19; Epidemiological parameter; VOC; Vaccine effectiveness.

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Conflict of interest statement

Declaration of competing interest The authors declare no competing interests.

Figures

Fig 1 — **Fig. 1**
Vaccination status and epidemiological parameters estimation of infections in COVID-19 outbreaks caused by Omicron BA.2, Omicron BA.1 and Delta. Vaccination status of infections from Omicron BA.2 (A), Omicron BA.1 (B) and Delta (C), respectively, and grouped by age. (D), Fitted serial interval (SI) distribution of paired cases of Delta (n = 83), Omicron BA.1 (n = 31) and BA.2 (n = 19). (E), Fitted incubation period (IP) distribution of cases of Delta (n = 74), Omicron BA.1 (n = 35) and BA.2 (n = 33). (F), The difference between IP and related SI of cases. (G), Fitted probability generation time (GT) distribution of infections of Delta (n = 58), Omicron BA.1 (n = 33) and BA.2 (n = 20). (H), Fitted transmission generation (TG) distribution of infections of Delta (n = 90), Omicron BA.1 (n = 32) and BA.2 (n = 20). (I), Effective reproductive number of difference outbreaks, estimated using R0 package.

Fig 2 — **Fig. 2**
Vaccination status of contacts and vaccine effectiveness against infections in COVID-19 outbreaks caused by Omicron BA.2, Omicron BA.1 and Delta. Vaccination status of contacts from Omicron BA.2 (A), Omicron BA.1 (B) and Delta (C), respectively, and grouped by age. Vaccine manufacturers with contacts in Omicron BA.2 (D), Omicron BA.1 (E) and Delta outbreaks (F), respectively. (G), Comparison of vaccine effectiveness against infection using a logistic regression model. (H), Comparison of vaccine effectiveness against infection using conditional logistic regression model, adjusted for age group.

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References

1. Zhang Y., Li J., Jiang L., et al. Comparison of SARS-CoV-2 aerosol emission from patients with Omicron BA.1 or BA.2 subvariant infection. J Infect. 2022;85(2) doi: 10.1016/j.jinf.2022.05.035. e37-e9. - DOI - PMC - PubMed
1. Yin Y., Li X., Qian C., Cheng B., Lu F., Shen T. Antibody efficacy of inactivated vaccine boosters (CoronaVac) against Omicron variant from a 15-month follow-up study. J Infect. 2022 doi: 10.1016/j.jinf.2022.06.018. - DOI - PMC - PubMed
1. Nishiura H., Ito K., Anzai A., Kobayashi T., Piantham C., Rodriguez-Morales A.J. Relative Reproduction Number of SARS-CoV-2 Omicron (B.1.1.529) compared with delta variant in South Africa. J Clin Med. 2021;11(1) doi: 10.3390/jcm11010030. - DOI - PMC - PubMed
1. Liu Y., Rocklov J. The effective reproduction number for the omicron SARS-CoV-2 variant of concern is several times higher than Delta. J Travel Med. 2022 doi: 10.1093/jtm/taac037. - DOI - PMC - PubMed
1. Johnson H. New Omicron variant: symptoms of Covid subvariant BA.2, how contagious is it and does it cause severe illness? 2022. https://www.nationalworld.com/health/new-omicron-variant-symptoms-of-cov... (accessed 15 April 2022).

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[1] Zhang Y., Li J., Jiang L., et al. Comparison of SARS-CoV-2 aerosol emission from patients with Omicron BA.1 or BA.2 subvariant infection. J Infect. 2022;85(2) doi: 10.1016/j.jinf.2022.05.035. e37-e9. - DOI - PMC - PubMed

[2] Zhang Y., Li J., Jiang L., et al. Comparison of SARS-CoV-2 aerosol emission from patients with Omicron BA.1 or BA.2 subvariant infection. J Infect. 2022;85(2) doi: 10.1016/j.jinf.2022.05.035. e37-e9. - DOI - PMC - PubMed

[3] Yin Y., Li X., Qian C., Cheng B., Lu F., Shen T. Antibody efficacy of inactivated vaccine boosters (CoronaVac) against Omicron variant from a 15-month follow-up study. J Infect. 2022 doi: 10.1016/j.jinf.2022.06.018. - DOI - PMC - PubMed

[4] Yin Y., Li X., Qian C., Cheng B., Lu F., Shen T. Antibody efficacy of inactivated vaccine boosters (CoronaVac) against Omicron variant from a 15-month follow-up study. J Infect. 2022 doi: 10.1016/j.jinf.2022.06.018. - DOI - PMC - PubMed

[5] Nishiura H., Ito K., Anzai A., Kobayashi T., Piantham C., Rodriguez-Morales A.J. Relative Reproduction Number of SARS-CoV-2 Omicron (B.1.1.529) compared with delta variant in South Africa. J Clin Med. 2021;11(1) doi: 10.3390/jcm11010030. - DOI - PMC - PubMed

[6] Nishiura H., Ito K., Anzai A., Kobayashi T., Piantham C., Rodriguez-Morales A.J. Relative Reproduction Number of SARS-CoV-2 Omicron (B.1.1.529) compared with delta variant in South Africa. J Clin Med. 2021;11(1) doi: 10.3390/jcm11010030. - DOI - PMC - PubMed

[7] Liu Y., Rocklov J. The effective reproduction number for the omicron SARS-CoV-2 variant of concern is several times higher than Delta. J Travel Med. 2022 doi: 10.1093/jtm/taac037. - DOI - PMC - PubMed

[8] Liu Y., Rocklov J. The effective reproduction number for the omicron SARS-CoV-2 variant of concern is several times higher than Delta. J Travel Med. 2022 doi: 10.1093/jtm/taac037. - DOI - PMC - PubMed

[9] Johnson H. New Omicron variant: symptoms of Covid subvariant BA.2, how contagious is it and does it cause severe illness? 2022. https://www.nationalworld.com/health/new-omicron-variant-symptoms-of-cov... (accessed 15 April 2022).

[10] Johnson H. New Omicron variant: symptoms of Covid subvariant BA.2, how contagious is it and does it cause severe illness? 2022. https://www.nationalworld.com/health/new-omicron-variant-symptoms-of-cov... (accessed 15 April 2022).

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Comparative analysis of transmission and vaccine effectiveness in Omicron and Delta variant outbreaks in China

Affiliations

Comparative analysis of transmission and vaccine effectiveness in Omicron and Delta variant outbreaks in China

Authors

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Conflict of interest statement

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