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Comment
. 2022 Oct;18(10):555-556.
doi: 10.1038/s41584-022-00820-5.

Kawasaki disease and MIS-C share a host immune response

Paul Tsoukas  1 , Rae S M Yeung  2   3
Affiliations
Comment

Kawasaki disease and MIS-C share a host immune response

Paul Tsoukas et al. Nat Rev Rheumatol. 2022 Oct.

Abstract

Multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease are both hyperinflammatory disorders associated with infectious diseases, but are they distinct syndromes or do they exist along a continuum? A comparison of the host immune response in these illnesses provides surprising new insights.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Post-infection hyperinflammation encompasses a spectrum of phenotypes.
Various infectious triggers prompt an invariant gene expression signature termed the viral pandemic (ViP) signature (yellow line). The intensity of the post-infectious immune response drives the clinical phenotype, which can range from mild hyperinflammation to macrophage activation syndrome (MAS) and cardiogenic shock. Expression of a subset of the ViP signature, termed severe ViP (sVIP) signature (red line), correlates with disease severity. Kawasaki disease and multisystem inflammatory syndrome in children (MIS-C) share a similar immunobiology and phenotype with overlapping features reflecting different parts of the disease spectrum.
See this image and copyright information in PMC

Comment on

References

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Publication types

Supplementary concepts