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. 2022 Aug 21;12(8):1112.
doi: 10.3390/brainsci12081112.

Potential Targets for Noninvasive Brain Stimulation on Depersonalization-Derealization Disorder

Sisi Zheng  1   2 , Nan Song  1   2 , Sici Wang  1   2 , Yanzhe Ning  1   2 , Hong Zhu  1   2 , Mingkang Song  1   2 , Yuan Jia  1   2 , Hongxiao Jia  1   2
Affiliations

Potential Targets for Noninvasive Brain Stimulation on Depersonalization-Derealization Disorder

Sisi Zheng et al. Brain Sci. .

Abstract

Introduction: Non-invasive brain stimulation seems to be beneficial for DPD patients. However, the sites used in previous studies were empirical. Exploring new stimulation locations via functional magnetic resonance imaging may improve the efficacy.

Objectives: The objective was to find potential locations for non-invasive brain stimulation on the depersonalization-derealization disorder.

Methods: We explored the potential brain surface regions from three pipelines: pipeline 1: activation likelihood estimation meta-analysis (five studies with 36 foci included); pipeline 2: functional connectivity analysis based on DPD-network (76 subjects included); and pipeline 3: functional connectivity analysis based on DPD regions of interest from the meta-analysis. Potential targets were the 10-20 system coordinates for brain surface regions.

Results: We identified several potential brain surface regions, including the bilateral medial prefrontal cortex, dorsal lateral prefrontal cortex, superior parietal gyrus, superior temporal gyrus, and right ventrolateral prefrontal cortex as potential sites.

Conclusion: Our findings of the potential stimulation targets might help clinicians optimize the application of non-invasive brain stimulation therapy in individuals with DPD.

Keywords: depersonalization-derealization disorder; functional connectivity; functional magnetic resonance imaging; non-invasive brain stimulation; transcranial magnetic stimulation.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
Potential targets for NIBS.
Figure 2
Figure 2
The results of sensitivity analyses (excluding treated patients).
See this image and copyright information in PMC

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