Comparison of synaptic changes in the precentral and postcentral cerebral cortex of aging humans: a quantitative ultrastructural study

Abstract

Ultrastructural quantitative analysis was undertaken to determine whether any age-related synaptic changes occur in cortical layer 1 of the human precentral motor gyrus (Brodmann's area 4) and postcentral somatosensory gyrus (Brodmann's area 3). Immersion fixed, osmicated, uranyl acetate/lead citrate stained (OsUL) preparations of autopsied brains were taken from patients aged 45 to 84 years, with no prior history of neurological or intellectual abnormalities. In the precentral gyrus there was a significant decrease in the number of synapses, which was primarily due to a decrease in asymmetrical axospinous synapses. Symmetrical synapses remained constant in number, while axodendritic synapses showed a small increase with age. Accompanying the decline in synapse number was an increase in mean length of the postsynaptic contact zone. In the postcentral gyrus there were no significant changes in synaptic number or in any of the synaptic parameters measured. The results suggest that the motor cortex of the human brain is capable of synaptic plasticity in response to aging-induced synaptic loss. This plasticity is not apparent in the somatosensory cortex, where there is no age-related synapse loss.