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. 2022 Jul 30;9(8):1153.
doi: 10.3390/children9081153.

The Management of Asymptomatic Congenital Pulmonary Airway Malformation: Results of a European Delphi Survey

Casper M Kersten  1 , Sergei M Hermelijn  1 , Dhanya Mullassery  2 , Nagarajan Muthialu  2 , Nazan Cobanoglu  3 , Silvia Gartner  4 , Pietro Bagolan  5 , Carmen Mesas Burgos  6 , Alberto Sgrò  7 , Stijn Heyman  8 , Holger Till  9 , Janne Suominen  10 , Maarten Schurink  11 , Liesbeth Desender  12 , Paul Losty  13 , Henri Steyaert  14 , Suzanne Terheggen-Lagro  15 , Martin Metzelder  16 , Arnaud Bonnard  17 , Rony Sfeir  18 , Michael Singh  19 , Iain Yardley  20 , Noor R V M Rikkers-Mutsaerts  21 , Cornelis K van der Ent  22 , Niels Qvist  23 , Des W Cox  24 , Robert Peters  25 , Michiel A G E Bannier  26 , Lucas Wessel  27 , Marijke Proesmans  28 , Michael Stanton  29 , Edward Hannon  30 , Marco Zampoli  31 , Francesco Morini  32 , Harm A W M Tiddens  33 , René M H Wijnen  1 , Johannes M Schnater  1
Affiliations

The Management of Asymptomatic Congenital Pulmonary Airway Malformation: Results of a European Delphi Survey

Casper M Kersten et al. Children (Basel). .

Abstract

Consensus on the optimal management of asymptomatic congenital pulmonary airway malformation (CPAM) is lacking, and comparison between studies remains difficult due to a large variety in outcome measures. We aimed to define a core outcome set (COS) for pediatric patients with an asymptomatic CPAM. An online, three-round Delphi survey was conducted in two stakeholder groups of specialized caregivers (surgeons and non-surgeons) in various European centers. Proposed outcome parameters were scored according to level of importance, and the final COS was established through consensus. A total of 55 participants (33 surgeons, 22 non-surgeons) from 28 centers in 13 European countries completed the three rounds and rated 43 outcome parameters. The final COS comprises seven outcome parameters: respiratory insufficiency, surgical complications, mass effect/mediastinal shift (at three time-points) and multifocal disease (at two time-points). The seven outcome parameters included in the final COS reflect the diversity in priorities among this large group of European participants. However, we recommend the incorporation of these outcome parameters in the design of future studies, as they describe measurable and validated outcomes as well as the accepted age at measurement.

Keywords: congenital lung abnormalities; congenital pulmonary airway malformation; consensus; core outcome set; outcome parameters.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of the 3-round Delphi Survey.
See this image and copyright information in PMC

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