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. 2022 Aug 18;19(16):10253.
doi: 10.3390/ijerph191610253.

Causes of Hospitalization among End-Stage Kidney Disease Cohort before and after Hemodialysis

Hsiu-Lan Li  1   2 , Pei-Hui Tai  3 , Yi-Ting Hwang  4 , Shih-Wei Lin  5   6   7 , Li-Ching Lan  8
Affiliations

Causes of Hospitalization among End-Stage Kidney Disease Cohort before and after Hemodialysis

Hsiu-Lan Li et al. Int J Environ Res Public Health. .

Abstract

Patients with end-stage kidney disease (ESKD) have a greater risk of comorbidities, including diabetes and anemia, and have higher hospital admission rates than patients with other diseases. The cause of hospital admissions is associated with ESKD prognosis. This retrospective cohort study involved patients with ESKD who received hemodialysis and investigated whether the cause of hospital admission changed before versus after they started hemodialysis. This study recruited 592 patients with ESKD who received hemodialysis at any period between January 2005 and November 2017 and had been assigned the International Classification of Diseases Ninth Revision Clinical Modification (ICD-9-CM) code for ESKD. The patients' demographic data and hospitalization status one year before and two years after they received hemodialysis were analyzed. A McNemar test was conducted to analyze the diagnostic changes from before to after hemodialysis in patients with ESKD. The study's sample of patients with ESKD comprised more women (51.86%) than men and had an average age of 67.15 years. The numbers of patients admitted to the hospital for the following conditions all decreased significantly after they received hemodialysis: type 2 (non-insulin-dependent and adult-onset) diabetes; native atherosclerosis; urinary tract infection; gastric ulcer without mention of hemorrhage, perforation, or obstruction; pneumonia; reflux esophagitis; duodenal ulcer without mention of hemorrhage, perforation, or obstruction; and bacteremia. Most patients exhibited one or more of the following comorbidities: diabetes (n = 407, 68.75%), hypertension (n = 491, 82.94%), congestive heart failure (n = 161, 27.20%), ischemic heart disease (n = 125, 21.11%), cerebrovascular accident (n = 93, 15.71%), and gout (n = 96, 16.22%). An analysis of variance (ANOVA) indicated that changes in the ICD-9-CM codes for native atherosclerosis, urinary tract infection, pneumonia, and hyperkalemia were associated with age. Patients who developed pneumonia before or after they received hemodialysis tended to be older (range: 69-70 years old). This study investigated the causes of hospital admission among patients with ESKD one year before and two years after they received hemodialysis. This study's results revealed hypertension to be the most common comorbidity. Regarding the cause of admission, pneumonia was more prevalent in older than in younger patients. Moreover, changes in the ICD-9-CM codes of native atherosclerosis, urinary tract infection, pneumonia, and hyperkalemia were significantly correlated with age. Therefore, when administering comprehensive nursing care and treatment for ESKD, clinicians should not only focus on comorbidities but also consider factors (e.g., age) that can affect patient prognosis.

Keywords: chronic hemodialysis; end-stage kidney disease; end-stage renal disease; hospitalizations.

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Conflict of interest statement

The authors declare no competing financial interest.

Figures

Figure 1
Figure 1
Patient flow chart of this study.
See this image and copyright information in PMC

References

    1. Collins A.J., Foley R.N., Gilbertson D.T., Chen S.-C. The state of chronic kidney disease, ESRD, and morbidity and mortality in the first year of dialysis. Clin. J. Am. Soc. Nephrol. 2009;4:S5–S11. doi: 10.2215/CJN.05980809. - DOI - PubMed
    1. Zhang A.-H., Cheng L.-T., Zhu N., Sun L.-H., Wang T. Comparison of quality of life and causes of hospitalization between hemodialysis and peritoneal dialysis patients in China. Health Qual. Life Outcomes. 2007;5:49. doi: 10.1186/1477-7525-5-49. - DOI - PMC - PubMed
    1. Go A.S., Chertow G.M., Fan D., McCulloch C.E., Hsu C.-y. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N. Engl. J. Med. 2004;351:1296–1305. doi: 10.1056/NEJMoa041031. - DOI - PubMed
    1. Teo B.W., Ma V., Xu H., Li J., Lee E.J., Group N.C.R. Profile of hospitalisation and death in the first year after diagnosis of end-stage renal disease in a multi-ethnic Asian population. Ann. Acad. Med. Singap. 2010;39:79. - PubMed
    1. Metcalfe W., Khan I., Prescott G., Simpson K., Macleod A.M. Hospitalization in the first year of renal replacement therapy for end-stage renal disease. QJM. 2003;96:899–909. doi: 10.1093/qjmed/hcg155. - DOI - PubMed

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