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Review
. 2022 Aug 11;23(16):8939.
doi: 10.3390/ijms23168939.

New Progress in Early Diagnosis of Atherosclerosis

Heyu Meng  1   2   3 , Jianjun Ruan  1   2   3 , Zhaohan Yan  1   2   3 , Yanqiu Chen  1   2   3 , Jinsha Liu  1   2   3 , Xiangdong Li  1   2   3 , Fanbo Meng  1   2   3
Affiliations
Review

New Progress in Early Diagnosis of Atherosclerosis

Heyu Meng et al. Int J Mol Sci. .

Abstract

Coronary atherosclerosis is a potentially chronic circulatory condition that endangers human health. The biological cause underpinning cardiovascular disease is coronary atherosclerosis, and acute cardiovascular events can develop due to thrombosis, platelet aggregation, and unstable atherosclerotic plaque rupture. Coronary atherosclerosis is progressive, and three specific changes appear, with fat spots and stripes, atherosclerosis and thin-walled fiber atherosclerosis, and then complex changes in arteries. The progression and severity of cardiovascular disease are correlated with various levels of calcium accumulation in the coronary artery. The therapy and diagnosis of coronary atherosclerosis benefit from the initial assessment of the size and degree of calcification. This article will discuss the new progress in the early diagnosis of coronary atherosclerosis in terms of three aspects: imaging, gene and protein markers, and trace elements. This study intends to present the latest methods for diagnosing patients with early atherosclerosis through a literature review.

Keywords: computed tomography coronary angiography; coronary atherosclerosis; genes; protein; trace element.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of the three examination modes of coronary atherosclerosis. From left to right are imaging examination, gene and protein marker examination, and trace element examination.
Figure 2
Figure 2
The entire process from gene to protein.
See this image and copyright information in PMC

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