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. 2022 Aug 12;11(16):4723.
doi: 10.3390/jcm11164723.

Efficacy of SARS-CoV-2 Vaccination in Dialysis Patients: Epidemiological Analysis and Evaluation of the Clinical Progress

Giovanni Mosconi  1 , Michela Fantini  2 , Matteo Righini  3 , Marta Flachi  4 , Simona Semprini  5 , Lilio Hu  1 , Francesca Chiappo  1 , Barbara Veterani  1 , Katia Ambri  1 , Franca Ferrini  1 , Catia Milanesi  1 , Antonio Giudicissi  1 , Gaetano La Manna  6 , Angelo Rigotti  4 , Andrea Buscaroli  3 , Vittorio Sambri  5 , Maria Cappuccilli  6
Affiliations

Efficacy of SARS-CoV-2 Vaccination in Dialysis Patients: Epidemiological Analysis and Evaluation of the Clinical Progress

Giovanni Mosconi et al. J Clin Med. .

Abstract

This study investigated the impact of the fourth COVID-19 pandemic wave on dialysis patients of Romagna territory, assessing the associations of vaccination status with infection risk, clinical severity and mortality. From November 2021 to February 2022, an epidemiological search was conducted on 829 patients under dialysis treatment for at least one month. The data were then analyzed with reference to the general population of the same area. A temporal comparison was also carried out with the previous pandemic waves (from March 2020 to October 2021). The epidemiological evolution over time in the dialysis population and in Romagna citizens replicated the global trend, as the peak of the fourth wave corresponded to the time of maximum diffusion of omicron variant (B.1.1.529). Of 771 prevalent dialysis patients at the beginning of the study, 109 (14.1%) contracted SARS-CoV-2 infection during the 4-month observation period. Vaccine adherence in the dialysis population of the reference area was above 95%. Compared to fully or partially vaccinated subjects, the unvaccinated ones showed a significantly higher proportion of infections (12.5% vs. 27.0% p = 0.0341), a more frequent need for hospitalization (22.2% vs. 50.0%) and a 3.3-fold increased mortality risk. These findings confirm the effectiveness of COVID-19 vaccines in keeping infectious risk under control and ameliorating clinical outcomes in immunocompromised patients.

Keywords: COVID-19; COVID-19 vaccination; SARS-CoV-2 infection; hemodialysis; immunodepressed patients; mRNA vaccines.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Weekly confirmed COVID-19 cases were divided according to Romagna territorial districts (Forlì, Cesena, Rimini and Ravenna) from 1 November 2021 to 28 February 2022.
Figure 2
Figure 2
Weekly confirmed COVID-19 new cases from 1 November 2021 to 28 February 2022 in the general population (blue bars) and in dialysis patients (red line) of Romagna territory.
See this image and copyright information in PMC

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