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Review
. 2022 Aug 16;11(16):4766.
doi: 10.3390/jcm11164766.

European Prevalence of Polypoidal Choroidal Vasculopathy: A Systematic Review, Meta-Analysis, and Forecasting Study

Elon H C van Dijk  1 , Jeppe K Holtz  2   3 , Marc J Sirks  4 , Janni M E Larsson  5 , Roselie M H Diederen  4 , Reinier O Schlingemann  4   6 , Camiel J F Boon  1   4 , Yousif Subhi  5   7
Affiliations
Review

European Prevalence of Polypoidal Choroidal Vasculopathy: A Systematic Review, Meta-Analysis, and Forecasting Study

Elon H C van Dijk et al. J Clin Med. .

Abstract

The purpose of this study was to provide an estimate of the number of current and future patients with polypoidal choroidal vasculopathy (PCV) in Europe. We systematically searched 11 literature databases on 18 May 2022 for studies on the prevalence of PCV among a consecutive and representative group of patients with suspected neovascular age-related macular degeneration (AMD). Prevalence of PCV in patients with suspected neovascular AMD was summarized and included in a prevalence meta-analysis. We then used current population data and population forecasts by Eurostat and the Office for National Statistics to determine current and future number of patients with neovascular AMD in Europe. Then, we calculated the number of patients with PCV with our calculated estimate of the prevalence of PCV among Europeans suspected with neovascular AMD. A total of five eligible studies were identified which included a total of 1359 patients. All these studies used the gold standard of indocyanine green angiography as a routine part of their diagnostic approach. Among patients undergoing detailed retinal examination for suspected neovascular AMD, our meta-analysis calculated the prevalence of PCV to be 8.3% (95% confidence interval: 6.8-9.8%). Our population estimates find that a total of 217,404 patients with PCV exist in Europe in the year 2022, which constitutes 0.04% of the entire population of Europe. This number is estimated to increase to 287,517 patients in the year 2040. Our estimates are important for different healthcare stakeholders, especially when planning and allocating expensive resources.

Keywords: Europe; forecasting; meta-analysis; polypoidal choroidal vasculopathy; prevalence; systematic review.

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Conflict of interest statement

Author Y.S. declares to have received a speaker’s fee from Bayer and Roche, and to be the inventor of a patent related to biomarkers of polypoidal choroidal vasculopathy (patent no. DK179993B1, https://patents.google.com/patent/DK179993B1/en?oq=DK179993B1, accessed on 12 August 2022), all of which are not directly related to this work. Other authors declare that no potential conflicts of interests exist in relation to this work.

Figures

Figure 1
Figure 1
PRISMA flow diagram of study selection.
See this image and copyright information in PMC

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