The Influence of Dietary Supplementations on Neuropathic Pain

doi:10.3390/life12081125

Review

. 2022 Jul 27;12(8):1125.

doi: 10.3390/life12081125.

The Influence of Dietary Supplementations on Neuropathic Pain

Francesco D'Egidio¹, Giorgia Lombardozzi¹, Housem E Kacem Ben Haj M'Barek¹, Giada Mastroiacovo¹, Margherita Alfonsetti¹, Annamaria Cimini^{1

2}

Affiliations

¹ Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
² Sbarro Institute for Cancer Research and Molecular Medicine and Center for Biotechnology, Temple University, Philadelphia, PA 19122, USA.

PMID: 36013304
PMCID: PMC9410423
DOI: 10.3390/life12081125

Review

The Influence of Dietary Supplementations on Neuropathic Pain

Francesco D'Egidio et al. Life (Basel). 2022.

. 2022 Jul 27;12(8):1125.

doi: 10.3390/life12081125.

Authors

Francesco D'Egidio¹, Giorgia Lombardozzi¹, Housem E Kacem Ben Haj M'Barek¹, Giada Mastroiacovo¹, Margherita Alfonsetti¹, Annamaria Cimini^{1

2}

Affiliations

¹ Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
² Sbarro Institute for Cancer Research and Molecular Medicine and Center for Biotechnology, Temple University, Philadelphia, PA 19122, USA.

PMID: 36013304
PMCID: PMC9410423
DOI: 10.3390/life12081125

Abstract

Neuropathic pain is defined as pain caused by a lesion or disease of the somatosensory nervous system and affects 7-10% of the worldwide population. Neuropathic pain can be induced by the use of drugs, including taxanes, thus triggering chemotherapy-induced neuropathic pain or as consequence of metabolic disorders such as diabetes. Neuropathic pain is most often a chronic condition, and can be associated with anxiety and depression; thus, it negatively impacts quality of life. Several pharmacologic approaches exist; however, they can lead numerous adverse effects. From this perspective, the use of nutraceuticals and diet supplements can be helpful in relieve neuropathic pain and related symptoms. In this review, we discuss how diet can radically affect peripheral neuropathy, and we focus on the potential approaches to ameliorate this condition, such as the use of numerous nutritional supplements or probiotics.

Keywords: CIPN; diabetic neuropathy; gut–brain axis; neuropathic pain; nutraceuticals; nutritional supplement.

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Conflict of interest statement

The authors declare no conflict of interest.

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[1] Ghoreishi Z., Esfahani A., Djazayeri A., Djalali M., Golestan B., Ayromlou H., Hashemzade S., Asghari Jafarabadi M., Montazeri V., Keshavarz S.A., et al. Omega-3 Fatty Acids Are Protective against Paclitaxel-Induced Peripheral Neuropathy: A Randomized Double-Blind Placebo Controlled Trial. BMC Cancer. 2012;12:355. doi: 10.1186/1471-2407-12-355. - DOI - PMC - PubMed

[2] Ghoreishi Z., Esfahani A., Djazayeri A., Djalali M., Golestan B., Ayromlou H., Hashemzade S., Asghari Jafarabadi M., Montazeri V., Keshavarz S.A., et al. Omega-3 Fatty Acids Are Protective against Paclitaxel-Induced Peripheral Neuropathy: A Randomized Double-Blind Placebo Controlled Trial. BMC Cancer. 2012;12:355. doi: 10.1186/1471-2407-12-355. - DOI - PMC - PubMed

[3] Kuhlwein A., Meyer H.J., Koehler C.O. Reduced diclofenac administration by B vitamins: Results of a randomized double-blind study with reduced daily doses of diclofenac (75 mg diclofenac versus 75 mg diclofenac plus B vitamins) in acute lumbar vertebral syndromes. Klin. Wochenschr. 1990;68:107–115. doi: 10.1007/BF01646857. - DOI - PubMed

[4] Kuhlwein A., Meyer H.J., Koehler C.O. Reduced diclofenac administration by B vitamins: Results of a randomized double-blind study with reduced daily doses of diclofenac (75 mg diclofenac versus 75 mg diclofenac plus B vitamins) in acute lumbar vertebral syndromes. Klin. Wochenschr. 1990;68:107–115. doi: 10.1007/BF01646857. - DOI - PubMed

[5] Jensen T.S., Baron R., Haanpää M., Kalso E., Loeser J.D., Rice A.S.C., Treede R.-D. A New Definition of Neuropathic Pain. Pain. 2011;152:2204–2205. doi: 10.1016/j.pain.2011.06.017. - DOI - PubMed

[6] Jensen T.S., Baron R., Haanpää M., Kalso E., Loeser J.D., Rice A.S.C., Treede R.-D. A New Definition of Neuropathic Pain. Pain. 2011;152:2204–2205. doi: 10.1016/j.pain.2011.06.017. - DOI - PubMed

[7] Colloca L., Ludman T., Bouhassira D., Baron R., Dickenson A.H., Yarnitsky D., Freeman R., Truini A., Attal N., Finnerup N.B., et al. Neuropathic Pain. Nat. Rev. Dis. Primers. 2017;3:1–19. doi: 10.1038/nrdp.2017.2. - DOI - PMC - PubMed

[8] Colloca L., Ludman T., Bouhassira D., Baron R., Dickenson A.H., Yarnitsky D., Freeman R., Truini A., Attal N., Finnerup N.B., et al. Neuropathic Pain. Nat. Rev. Dis. Primers. 2017;3:1–19. doi: 10.1038/nrdp.2017.2. - DOI - PMC - PubMed

[9] Scholz J., Finnerup N.B., Attal N., Aziz Q., Baron R., Bennett M.I., Benoliel R., Cohen M., Cruccu G., Davis K.D., et al. The IASP Classification of Chronic Pain for ICD-11: Chronic Neuropathic Pain. Pain. 2019;160:53–59. doi: 10.1097/j.pain.0000000000001365. - DOI - PMC - PubMed

[10] Scholz J., Finnerup N.B., Attal N., Aziz Q., Baron R., Bennett M.I., Benoliel R., Cohen M., Cruccu G., Davis K.D., et al. The IASP Classification of Chronic Pain for ICD-11: Chronic Neuropathic Pain. Pain. 2019;160:53–59. doi: 10.1097/j.pain.0000000000001365. - DOI - PMC - PubMed

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The Influence of Dietary Supplementations on Neuropathic Pain

Affiliations

The Influence of Dietary Supplementations on Neuropathic Pain

Authors

Affiliations

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Conflict of interest statement

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Abstract

Conflict of interest statement

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