Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Aug 4;58(8):1049.
doi: 10.3390/medicina58081049.

Insomnia Complaints and Perceived Immune Fitness in Young Adults with and without Self-Reported Impaired Wound Healing

Jessica Balikji  1 , Maarten M Hoogbergen  2 , Johan Garssen  1   3 , Thomas Roth  4 , Joris C Verster  1   5
Affiliations

Insomnia Complaints and Perceived Immune Fitness in Young Adults with and without Self-Reported Impaired Wound Healing

Jessica Balikji et al. Medicina (Kaunas). .

Abstract

Background and Objectives: Adequate sleep and an effective immune system are both essential to maintain a good health status. The current study aimed to determine the nature of insomnia complaints and perceived immune fitness among Dutch young adults with and without self-reported impaired wound healing. Materials and Methods: A total of (n = 2033) Dutch students (83.8% women) completed an online survey. Perceived immune fitness was assessed with a single-item scale and insomnia complaints with the SLEEP-50 insomnia subscale. The sample comprised a control group without self-reported impaired wound healing (n = 1622), a wound infection (WI) group (n = 69), a slow healing wounds (SHW) group (n = 250), and a COMBI group that experienced both WI and SHW (n = 92). Results: Comparisons with the control group revealed that individuals of the SHW and COMBI groups reported significantly poorer perceived immune functioning, increased insomnia complaints and daytime fatigue, and poorer sleep quality. Conclusions: Individuals with self-reported impaired wound healing have a poorer perceived immune functioning, increased insomnia complaints, daytime fatigue, and poorer sleep quality.

Keywords: fatigue; insomnia; perceived immune fitness; sleep complaints; slow healing wounds; wound healing; wound infection.

PubMed Disclaimer

Conflict of interest statement

Over the past three years, J.C.V. has acted as a consultant/advisor for KNMP, Mentis, Red Bull, Sen-Jam Pharmaceutical, and Toast!. J.G. is a part-time employee of Nutricia Research and received research grants from the Nutricia Research Foundation, Top Institute Pharma, Top Institute Food and Nutrition, GSK, STW, NWO, Friesland Campina, CCC, Raak-Pro, and EU. T.R. has received grants/research support from Aventis, Cephalon, Glaxo Smith Kline, Neurocrine, Pfizer, Sanofi, Schering-Plough, Sepracor, Somaxon, Syrex, Takeda, TransOral, Wyeth, and Xeno-port and has acted as a consultant for Abbott, Acadia, Acoglix, Actelion, Alchemers, Alza, Ancil, Arena, Astra Zeneca, Aventis, AVER, BMS, BTG, Cephalon, Cypress, Dove, Elan, Eli Lilly, Evotec, Forest, Glaxo Smith Kline, Hypnion, Impax, Intec, Intra-Cellular, Jazz, Johnson & Johnson, King, Lundbeck, McNeil, Medici Nova, Merck, Neurim, Neurocrine, Neurogen, Novartis, Orexo, Or-ganon, Prestwick, Procter-Gamble, Pfizer, Purdue, Resteva, Roche, Sanofi, Schering-Plough, Sepracor, Servier, Shire, Somaxon, Syrex, Takeda, TransOral, Vanda, Vivometrics, Wyeth, Yamanuchi, and Xenoport. The other authors have no potential conflicts of interest to disclose.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Lorton D., Lubahn C.L., Estus C., Millar B.A., Carter J.L., Wood C.A., Bellinger D.L. Bidirectional communication between the brain and the immune system: Implications for physiological sleep and disorders with disrupted sleep. Neuroimmunomodulation. 2006;13:357–374. doi: 10.1159/000104864. - DOI - PubMed
    1. Faraut B., Boudjeltia K.Z., Vanhamme L., Kerkhofs M. Immune, inflammatory and cardiovascular consequences of sleep restriction and recovery. Sleep Med. Rev. 2012;16:137–149. doi: 10.1016/j.smrv.2011.05.001. - DOI - PubMed
    1. Wilder-Smith A., Mustafa F.B., Earnest A., Gen L., Macary P.A. Impact of partial sleep deprivation on immune markers. Sleep Med. 2013;14:1031–1034. doi: 10.1016/j.sleep.2013.07.001. - DOI - PubMed
    1. Lange T., Dimitrov S., Born J. Effects of sleep and circadian rhythm on the human immune system. Ann. N. Y. Acad. Sci. 2010;1193:48–59. doi: 10.1111/j.1749-6632.2009.05300.x. - DOI - PubMed
    1. Majde J.A., Krueger J.M. Links between the innate immune system and sleep. J. Allergy Clin. Immunol. 2005;116:1188–1198. doi: 10.1016/j.jaci.2005.08.005. - DOI - PubMed