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Observational Study
. 2022 Aug 5;58(8):1057.
doi: 10.3390/medicina58081057.

Bilateral Seminal Vesicle Invasion Is Not Associated with Worse Outcomes in Locally Advanced Prostate Carcinoma

Natalia Vidal Crespo  1 , Laura Enguita Arnal  2 , Álvaro Gómez-Ferrer  3 , Argimiro Collado Serra  3 , Juan Manuel Mascarós  3 , Ana Calatrava Fons  4 , Juan Casanova Ramón-Borja  3 , José Rubio Briones  3 , Miguel Ramírez-Backhaus  3
Affiliations
Observational Study

Bilateral Seminal Vesicle Invasion Is Not Associated with Worse Outcomes in Locally Advanced Prostate Carcinoma

Natalia Vidal Crespo et al. Medicina (Kaunas). .

Abstract

Background and Objectives: Patients with seminal vesicle invasion (SVI) are a highly heterogeneous group. Prognosis can be affected by many clinical and pathological characteristics. Our aim was to study whether bilateral SVI (bi-SVI) is associated with worse oncological outcomes. Materials and Methods: This is an observational retrospective study that included 146 pT3b patients treated with radical prostatectomy (RP). We compared the results between unilateral SVI (uni-SVI) and bi-SVI. The log-rank test and Kaplan-Meier curves were used to compare biochemical recurrence-free survival (BCR), metastasis-free survival (MFS), and additional treatment-free survival. Cox proportional hazard models were used to identify predictors of BCR-free survival, MFS, and additional treatment-free survival. Results: 34.93% of patients had bi-SVI. The median follow-up was 46.84 months. No significant differences were seen between the uni-SVI and bi-SVI groups. BCR-free survival at 5 years was 33.31% and 25.65% (p = 0.44) for uni-SVI and bi-SVI. MFS at 5 years was 86.03% vs. 75.63% (p = 0.1), and additional treatment-free survival was 36.85% vs. 21.93% (p = 0.09), respectively. In the multivariate analysis, PSA was related to the development of BCR [HR 1.34 (95%CI: 1.01-1.77); p = 0.03] and metastasis [HR 1.83 (95%CI: 1.13-2.98); p = 0.02]. BCR was also influenced by lymph node infiltration [HR 2.74 (95%CI: 1.41-5.32); p = 0.003]. Additional treatment was performed more frequently in patients with positive margins [HR: 3.50 (95%CI: 1.65-7.44); p = 0.001]. Conclusions: SVI invasion is an adverse pathology feature, with a widely variable prognosis. In our study, bilateral seminal vesicle invasion did not predict worse outcomes in pT3b patients despite being associated with more undifferentiated tumors.

Keywords: biochemical recurrence; prostate cancer; radical prostatectomy; seminal vesicle invasion; survival.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Kaplan–Meier curves showing BCR-free survival for both uni-SVI and bi-SVI groups.
Figure 2
Figure 2
Kaplan–Meier curves showing MFS for both uni-SVI and bi-SVI groups.
Figure 3
Figure 3
Kaplan–Meier curves showing additional treatment-free survival for both uni-SVI and bi-SVI groups.
See this image and copyright information in PMC

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