Nano-Lipids Based on Ginger Oil and Lecithin as a Potential Drug Delivery System
- PMID: 36015280
- PMCID: PMC9412309
- DOI: 10.3390/pharmaceutics14081654
Nano-Lipids Based on Ginger Oil and Lecithin as a Potential Drug Delivery System
Abstract
Lipid nanoparticles based on lecithin are an interesting part of drug delivery systems. However, the stability of lecithin nano-lipids is problematic due to the degradation of lecithin, causing a decrease in pH. In this study, the modification of the conventional nano-lipid-based soybean lecithin was demonstrated. Ginger-oil-derived Zingiber officinale was used along with lecithin, cholesterol and span 80 to fabricate nano-lipids (GL nano-lipids) using a thin-film method. TEM and a confocal microscope were used to elucidate GL nano-lipids' liposome-like morphology. The average size of the resultant nano-lipid was 249.1 nm with monodistribution (PDI = 0.021). The ζ potential of GL nano-lipids was negative, similarly to as-prepared nano-lipid-based lecithin. GL nano-lipid were highly stable over 60 days of storage at room temperature in terms of size and ζ potential. A shift in pH value from alkaline to acid was detected in lecithin nano-lipids, while with the incorporation of ginger oil, the pH value of nano-lipid dispersion was around 7.0. Furthermore, due to the richness of shogaol-6 and other active compounds in ginger oil, the GL nano-lipid was endowed with intrinsic antibacterial activity. In addition, the sulforhodamine B (SRB) assay and live/dead imaging revealed the excellent biocompatibility of GL nano-lipids. Notably, GL nano-lipids were capable of carrying hydrophobic compounds such as curcumin and performed a pH-dependent release profile. A subsequent characterization showed their suitable potential for drug delivery systems.
Keywords: drug delivery system; essential oil; ginger oil; lecithin; nano-lipid.
Conflict of interest statement
Authors would like to thank Nguyen Ngoc Tuan (Institute of Biotechnology and Food Technology, Industrial University of Ho Chi Minh City, for identification of plant specimens. We gratefully thank the Department of Biochemistry, Faculty of Biology and Biotechnology, University of Science, Vietnam National University, Ho Chi Minh City, for providing bacterial strains.
Figures






References
-
- Hou Y., Li J., Guan S., Witte F. The therapeutic potential of MSC-EVs as a bioactive material for wound healing. Eng. Regen. 2022;2:182–194. doi: 10.1016/j.engreg.2021.11.003. - DOI
-
- Vicario-de-la-Torre M., Caballo-González M., Vico E., Morales-Fernández L., Arriola-Villalobos P., De las Heras B., Benítez-del-Castillo J.M., Guzmán M., Millar T., Herrero-Vanrell R., et al. Novel nano-liposome formulation for dry eyes with components similar to the preocular tear film. Polymers. 2018;10:425. doi: 10.3390/polym10040425. - DOI - PMC - PubMed
LinkOut - more resources
Full Text Sources