Goldilocks and the Three Trials: Clinical Trials Targeting the αvβ6 Integrin in Idiopathic Pulmonary Fibrosis
- PMID: 36018580
- PMCID: PMC9704830
- DOI: 10.1164/rccm.202208-1579ED
Goldilocks and the Three Trials: Clinical Trials Targeting the αvβ6 Integrin in Idiopathic Pulmonary Fibrosis
Comment on
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A Phase IIb Randomized Clinical Study of an Anti-αvβ6 Monoclonal Antibody in Idiopathic Pulmonary Fibrosis.Am J Respir Crit Care Med. 2022 Nov 1;206(9):1128-1139. doi: 10.1164/rccm.202112-2824OC. Am J Respir Crit Care Med. 2022. PMID: 35771569 Clinical Trial.
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Randomized Phase IIa Clinical Study of an Anti-αvβ6 Monoclonal Antibody in Idiopathic Pulmonary Fibrosis.Am J Respir Crit Care Med. 2022 Nov 1;206(9):1166-1168. doi: 10.1164/rccm.202205-0868LE. Am J Respir Crit Care Med. 2022. PMID: 35830489 Free PMC article. Clinical Trial. No abstract available.
References
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- Raghu G, Mouded M, Chambers DC, Martinez FJ, Richeldi L, Lancaster LH, et al. A phase IIb randomized clinical study of an anti-αvβ6 monoclonal antibody in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med . 2022;206:1128–1139. - PubMed
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- Koivisto L, Bi J, Häkkinen L, Larjava H. Integrin αvβ6: structure, function and role in health and disease. Int J Biochem Cell Biol . 2018;99:186–196. - PubMed
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- Munger JS, Huang X, Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, et al. The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell . 1999;96:319–328. - PubMed
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- Horan GS, Wood S, Ona V, Li DJ, Lukashev ME, Weinreb PH, et al. Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation. Am J Respir Crit Care Med . 2008;177:56–65. - PubMed
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