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. 1978 Sep;75(9):4465-9.
doi: 10.1073/pnas.75.9.4465.

Relative sensitivities of forward and reverse mutation assays in Salmonella typhimurium

T R Skopek, H L Liber, D A Kaden, W G Thilly

Relative sensitivities of forward and reverse mutation assays in Salmonella typhimurium

T R Skopek et al. Proc Natl Acad Sci U S A. 1978 Sep.

Abstract

Forward mutation to 8-azaguanine resistance and reverse mutation to histidine prototrophy were measured in Salmonella typhimurium after treatment with 16 mutagens of both base-substitution and frameshift classes. The two approaches were found to be equisensitive for all 16 mutagens--i.e., induction of significant mutation occurred at similar concentrations in the forward mutation assay and in the most sensitive of the five Ames tester strains.

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References

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