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Multicenter Study
. 2022 Oct;160(1):101-106.
doi: 10.1007/s11060-022-04120-6. Epub 2022 Aug 27.

Is intracranial volume a risk factor for IDH-mutant low-grade glioma? A case-control study

Lisa Millgård Sagberg #  1   2 , Even Hovig Fyllingen #  3   4 , Tor Ivar Hansen  5   6 , Per Sveino Strand  7   5 , Aril Løge Håvik  8   9 , Terje Sundstrøm  8   10 , Alba Corell  11   12 , Asgeir Store Jakola  11   12 , Øyvind Salvesen  13 , Ole Solheim  7   5
Affiliations
Multicenter Study

Is intracranial volume a risk factor for IDH-mutant low-grade glioma? A case-control study

Lisa Millgård Sagberg et al. J Neurooncol. 2022 Oct.

Abstract

Purpose: Risk of cancer has been associated with body or organ size in several studies. We sought to investigate the relationship between intracranial volume (ICV) (as a proxy for lifetime maximum brain size) and risk of IDH-mutant low-grade glioma.

Methods: In a multicenter case-control study based on population-based data, we included 154 patients with IDH-mutant WHO grade 2 glioma and 995 healthy controls. ICV in both groups was calculated from 3D MRI brain scans using an automated reverse brain mask method, and then compared using a binomial logistic regression model.

Results: We found a non-linear association between ICV and risk of glioma with increasing risk above and below a threshold of 1394 ml (p < 0.001). After adjusting for ICV, sex was not a risk factor for glioma.

Conclusion: Intracranial volume may be a risk factor for IDH-mutant low-grade glioma, but the relationship seems to be non-linear with increased risk both above and below a threshold in intracranial volume.

Keywords: Brain neoplasms; HUNT study; Low-grade glioma; Magnetic resonance imaging; Risk factors.

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Conflict of interest statement

The authors have no relevant financial or non-financial interests to disclose.

Figures

Fig. 1
Fig. 1
Flow chart of the inclusion process
Fig. 2
Fig. 2
Distributions of intracranial volumes in cases and controls
Fig. 3
Fig. 3
Odds ratio of IDH-mutant low-grade glioma based on ICV. Graph is presented within the upper and lower range limits for ICV. The diamond shaped marker illustrates the ICV value of lowest risk
See this image and copyright information in PMC

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