doi: 10.1016/j.parkreldis.2022.08.004.
Epub 2022 Aug 19.
Personality assessment with Temperament and Character Inventory in Parkinson's disease
Mathilde Boussac
1
, Christophe Arbus
2
, Olivier Colin
3
, Chloé Laurencin
4
, Alexandre Eusebio
5
, Elodie Hainque
6
, Jean Christophe Corvol
6
, Nathalie Versace
7
, Olivier Rascol
8
, Vanessa Rousseau
9
, Estelle Harroch
9
, Fabienne Ory-Magne
8
, Margherita Fabbri
8
, Caroline Moreau
10
, Anne-Sophie Rolland
10
, Béchir Jarraya
11
, David Maltête
12
, Sophie Drapier
13
, Ana-Raquel Marques
14
, Nicolas Auzou
15
, Thomas Wirth
16
, Mylène Meyer
17
, Bruno Giordana
18
, Mélissa Tir
19
, Tiphaine Rouaud
20
, David Devos
10
, Christine Brefel-Courbon
8
; PREDISTIM study group
Collaborators,
Affiliations
Collaborators
-
PREDISTIM study group:
Caroline Moreau 21 , Pr Luc Defebvre 21 , Dr Nicolas Carriere 21 , Dr Guillaume Grolez 21 , Dr Guillaume Baille 21 , Dr Kreisler 21 , Pr Jean-Pierre Pruvo 21 , Pr Leclerc 21 , Dr Renaud Lopes 21 , Dr Romain Viard 21 , Dr Gregory Kuchcinski 21 , Mr Julien Dumont 21 , Pr Kathy Dujardin 21 , Mme M Delliaux 21 , Mrs M Brion 21 , Dr Gustavo Touzet 21 , Pr Nicolas Reyns 21 , Pr Arnaud Delval 21 , Mrs Valerie Santraine 21 , Mrs Marie Pleuvret 21 , Mrs Nolwen Dautrevaux 21 , Mr Victor Laugeais 21 , Thavarak Ouk 21 , Camille Potey 21 , Celine Leclercq 21 , Elise Gers 21 , Jean-Christophe Corvol 22 , Marie-Vidailhet 22 , Elodie Hainque 22 , Marie-Laure Welter 22 , Lucette Lacomblez 22 , David Grabli 22 , Emmanuel Roze 22 , Yulia Worbe 22 , Cécile Delorme 22 , Hana You 22 , Jonas Ihle 22 , Raquel Guimeraes-Costa 22 , Florence Cormier-Dequaire 22 , Aurélie Méneret 22 , Andréas Hartmann 22 , Louise-Laure Mariani 22 , Stéphane Lehericy 22 , Virginie Czernecki 22 , Fanny Pineau 22 , Frédérique Bozon 22 , Camille Huiban 22 , Eve Benchetrit 22 , Carine Karachi 22 , Soledad Navarro 22 , Philippe Cornu 22 , Arlette Welaratne 22 , Carole Dongmo-Kenfack 22 , Lise Mantisi 22 , Nathalie Jarry 22 , Sophie Aix 22 , Carine Lefort 22 , Dr Tiphaine Rouaud 23 , Pr Philippe Damier 23 , Pr Pascal Derkinderen 23 , Dr Anne-Gaelle Corbille 23 , Dr Elisabeth Calvier-Auffray 23 , Mrs Laetitia Rocher 23 , Mrs Anne-Laure Deruet 23 , Dr Raoul Sylvie 23 , Dr Roualdes Vincent 23 , Mrs Le Dily Séverine 23 , Dr Ana Marques 24 , Dr Berangere Debilly 24 , Pr Franck Durif 24 , Dr Philippe Derost 24 , Dr Charlotte Beal 24 , Carine Chassain 24 , Laure Delaby 24 , Tiphaine Vidal 24 , Pr Jean Jacques Lemaire 24 , Isabelle Rieu 24 , Elodie Durand 24 , Pr Alexandre Eusebio 25 , Pr Jean-Philippe Azulay 25 , Dr Tatiana Witjas 25 , Dr Frédérique Fluchère 25 , Dr Stephan Grimaldi 25 , Pr Nadine Girard 25 , Eve Benchetrit 25 , Marie Delfini 25 , Dr Romain Carron 25 , Pr Jean Regis 25 , Dr Giorgio Spatola 25 , Camille Magnaudet 25 , Dr Ansquer Solène 26 , Dr Benatru Isabelle 26 , Dr Colin Olivier 26 , Pr Houeto Jl 26 , Pr Guillevin Remy 26 , Mrs Fradet Anne 26 , Mrs Anziza Manssouri 26 , Mrs Blondeau Sophie 26 , Dr Richard Philippe 26 , Dr Cam Philippe 26 , Dr Page Philippe 26 , Pr Bataille Benoit 26 , Mrs Rabois Emilie 26 , Mrs Guillemain Annie 26 , Dr Drapier Sophie 27 , Dr Frédérique Leh 27 , Dr Alexandre Bonnet 27 , Pr Marc Vérin 27 , Dr Jean-Christophe Ferré 27 , Mr Jean François Houvenaghel 27 , Pr Claire Haegelen 27 , Mrs Francoise Kestens 27 , Mrs Solenn Ory 27 , Pr Pierre Burbaud 28 , Dr Nathalie Damon-Perriere 28 , Pr Wassilios Meissner 28 , Pr Francois Tison 28 , Dr Stéphanie Bannier 28 , Dr Elsa Krim 28 , Pr Dominique Guehl 28 , Sandrine Molinier-Blossier 28 , Morgan Ollivier 28 , Marion Lacoste 28 , Nicolas Auzou 28 , Marie Bonnet 28 , Pr Emmanuel Cuny 28 , Dr Julien Engelhardt 28 , Olivier Branchard 28 , Clotilde Huet 28 , Julie Blanchard 28 , Pr Rascol Olivier 29 , Dr Christine Brefel Courbon 29 , Dr Fabienne Ory Magne 29 , Dr Marion Simonetta Moreau 29 , Pr Christophe Arbus 29 , Pr Fabrice Bonneville 29 , Dr Jean Albert Lotterie 29 , Marion Sarrail 29 , Charlotte Scotto d'Apollonia 29 , Pr Patrick Chaynes 29 , Pr François Caire 29 , Estelle Harroch 29 , Pr David Maltete 30 , Dr Romain Lefaucheur 30 , Dr Damien Fetter 30 , Dr Nicolas Magne 30 , Mrs Sandrine Bioux 30 , Mrs Maud Loubeyre 30 , Mrs Evangéline Bliaux 30 , Mrs Dorothée Pouliquen 30 , Pr Stéphane Derrey 30 , Mrs Linda Vernon 30 , Dr Frédéric Ziegler 30 , Mathieu Anheim 31 , Ouhaid Lagha-Boukbiza 31 , Christine Tranchant 31 , Odile Gebus 31 , Solveig Montaut 31 , S Kremer 31 , Nadine Longato 31 , Clélie Phillips 31 , Jimmy Voirin 31 , Marie des Neiges Santin 31 , Dominique Chaussemy 31 , Dr Amaury Mengin 31 , Dr Caroline Giordana 32 , Dr Claire Marsé 32 , Lydiane Mondot 32 , Bruno Giordana 32 , Robin Kardous 32 , Bernadette Bailet 32 , Héloise Joly 32 , Denys Fontaine 32 , Dr Aurélie Leplus 32 , Amélie Faustini 32 , Vanessa Ferrier 32 , Pr Pierre Krystkowiak 33 , Dr Mélissa Tir 33 , Pr Jean-Marc Constans 33 , Sandrine Wannepain 33 , Audrey Seling 33 , Dr Michel Lefranc 33 , Stéphanie Blin 33 , Béatrice Schuler 33 , Pr Stephane Thobois 34 , Dr Teodor Danaila 34 , Dr Chloe Laurencin 34 , Pr Yves Berthezene 34 , Dr Roxana Ameli 34 , Helene Klinger 34 , Dr Gustavo Polo 34 , Patrick Mertens 34 , A Nunes 34 , Elise Metereau 34 , Dr Lucie Hopes 35 , Dr Solène Frismand 35 , Dr Emmanuelle Schmitt 35 , Mrs Mylène Meyer 35 , Mrs Céline Dillier 35 , Pr Sophie Colnat 35 , Mrs Anne Chatelain 35 , Dr Jean- Philippe Brandel 36 , Dr Cécile Hubsch 36 , Dr Patte Karsenti 36 , Dr Marie Lebouteux 36 , Dr Marc Ziegler 36 , Dr Christine Delmaire 36 , Dr Julien Savatowky 36 , Mrs Juliette Vrillac 36 , Mrs Claire Nakache 36 , Dr Vincent D'Hardemare 36 , Mr Lhaouas Belamri 36 , Dr Valérie Mesnage 37 , Dr Cécilia Bonnet 37 , Dr Jarbas Correa Lino Jr 37 , Dr Camille Decrocq 37 , Dr Anne Boulin 37 , Mrs Inès Barre 37 , Mrs Jordane Manouvrier 37 , Dr Bérénice Gardel 37 , Pr Béchir Jarraya 37 , Mrs Catherine Ziz 37 , Mrs Lydie Prette 37 , Mr Hassen Douzane 37 , David Gay 38 , Robin Bonicel 38 , Fouzia El Mountassir 38 , Clara Fischer 38 , Jean-François Mangin 38 , Marie Chupin 38 , Yann Cointepas 38 , Bertrand Accart 39 , Patrick Gelé 39 , Florine Fievet 39 , Matthieu Chabel 39 , Virginie Derenaucourt 39 , Loïc Facon 39 , Yanick Tchantchou Njosse 39 , Dominique Deplanque 39 , Alain Duhamel 40 , Lynda Djemmane 40 , Florence Duflot 40
Affiliations
- 1 Toulouse NeuroImaging Center, University of Toulouse, Inserm, UPS, France. Electronic address: mathilde.boussac@inserm.fr.
- 2 Psychiatry Department of the University Hospital of Toulouse, CHU Purpan, Toulouse, France.
- 3 Service de neurologie, Centre Hospitalier de Brive-la-Gaillarde, France; Centre Expert Parkinson, CHU de Limoges, France.
- 4 Service de neurologie C - Hôpital Neurologique - 59 boulevard Pinel 69003 Lyon - Hospices Civils de Lyon, France.
- 5 Aix Marseille Université, AP-HM, Hôpital de La Timone, Service de Neurologie et Pathologie du Mouvement, and UMR CNRS 7289, Institut de Neuroscience de La Timone, NS-PARK/FCRIN Network, Marseille, France.
- 6 Département de Neurologie, Hôpital Pitié-Salpêtrière, AP-HP, Paris, France; et Faculté de Médecine de Sorbonne Université, UMR S 1127, Inserm U 1127, and CNRS UMR 7225, and Institut du Cerveau, F-75013, Paris, France.
- 7 Department of Neurology, Hôpital Fondation Rothschild, Paris, France.
- 8 Toulouse NeuroImaging Center, University of Toulouse, Inserm, UPS, France; Department of Clinical Pharmacology and Neurosciences, Parkinson Expert Center, Clinical Investigation Center CIC1436, University Hospital of Toulouse, NeuroToul COEN (Center of Excellence in Neurodegeneration), Toulouse, NS-PARK/FCRIN Network, France.
- 9 Department of Clinical Pharmacology and Neurosciences, Parkinson Expert Center, Clinical Investigation Center CIC1436, University Hospital of Toulouse, NeuroToul COEN (Center of Excellence in Neurodegeneration), Toulouse, NS-PARK/FCRIN Network, France.
- 10 Department of Medical Pharmacology, Neurology and Movement Disorders Department, Referent Center of Parkinson's disease, CHU of Lille, Univ. Lille Neuroscience & Cognition, Inserm, UMR-S1172, Licend, Lille, NS-PARK/FCRIN Network, France.
- 11 Service de Neurologie, Unité des Mouvements Anormaux, Foch Hospital, Suresnes, France; Université de Versailles Paris-Saclay, INSERM U992, CEA Neurospin, Saclay, France.
- 12 Department of Neurology, Rouen University Hospital and University of Rouen, France; INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Mont-Saint-Aignan, France.
- 13 Service de neurologie, CHU Rennes, CIC INSERM, 1414, Rennes, France.
- 14 Université Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand University Hospital, Neurology department, France.
- 15 Institut des Maladies neurodégénératives, Pôle des neurosciences cliniques, CHU Bordeaux, France; Service de neurophysiologie clinique de l'enfant et de l'adulte, Pôle des neurosciences cliniques, CHU Bordeaux, France.
- 16 Service de Neurologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France; Institut de Génétique et de Biologie Moléculaire et Cellulaire, INSERM-U964/CNRSUMR7104/Université de Strasbourg, Illkirch-Graffenstaden, France; Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Strasbourg, France.
- 17 Neurology Department of the University Hospital of Nancy, CHRU de Nancy, Nancy, France.
- 18 CHU Nice, Department of Psychiatry and Psychotherapy, Nice, France.
- 19 Department of Neurology, Department of Neurosurgery, Expert Centre for Parkinson's disease, Amiens University Hospital, EA 4559 Laboratoire de Neurosciences Fonctionnelles et Pathologie (LNFP) Université de Picardie Jules Verne, University of Picardy Jules Verne (UPJV), NS-PARK/FCRIN Network, Amiens, France.
- 20 Department of Neurology, Expert Centre for Parkinson's Disease, University Hospital of Nantes, Nantes, France.
- 21 Lille University Hospital, France.
- 22 AP-HP, Paris, France.
- 23 Nantes University Hospital, France.
- 24 Clermont-Ferrand University Hospital, France.
- 25 AP-HM, Marseille, France.
- 26 Poitiers University Hospital, France.
- 27 Rennes University Hospital, France.
- 28 Bordeaux University Hospital, France.
- 29 Toulouse University Hospital, France.
- 30 Rouen University Hospital, France.
- 31 Strasbourg University Hospital, France.
- 32 Nice University Hospital, France.
- 33 Amiens University Hospital, France.
- 34 Lyon University Hospital, France.
- 35 Nancy University Hospital, France.
- 36 Rotschild fondation of Paris, France.
- 37 Foch Hospital of Paris-Saclay University, France.
- 38 CATI, MRI acquisition Management, Preprocessing and data Management, France.
- 39 CRB of Lille (Center of Biological Resources), France.
- 40 Data Management of Lille, France.
- PMID: 36030666
- DOI: 10.1016/j.parkreldis.2022.08.004
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Personality assessment with Temperament and Character Inventory in Parkinson's disease
Mathilde Boussac et al.
Parkinsonism Relat Disord.
2022 Oct.
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doi: 10.1016/j.parkreldis.2022.08.004.
Epub 2022 Aug 19.
Authors
Mathilde Boussac
1
, Christophe Arbus
2
, Olivier Colin
3
, Chloé Laurencin
4
, Alexandre Eusebio
5
, Elodie Hainque
6
, Jean Christophe Corvol
6
, Nathalie Versace
7
, Olivier Rascol
8
, Vanessa Rousseau
9
, Estelle Harroch
9
, Fabienne Ory-Magne
8
, Margherita Fabbri
8
, Caroline Moreau
10
, Anne-Sophie Rolland
10
, Béchir Jarraya
11
, David Maltête
12
, Sophie Drapier
13
, Ana-Raquel Marques
14
, Nicolas Auzou
15
, Thomas Wirth
16
, Mylène Meyer
17
, Bruno Giordana
18
, Mélissa Tir
19
, Tiphaine Rouaud
20
, David Devos
10
, Christine Brefel-Courbon
8
; PREDISTIM study group
Collaborators
-
PREDISTIM study group:
Caroline Moreau 21 , Pr Luc Defebvre 21 , Dr Nicolas Carriere 21 , Dr Guillaume Grolez 21 , Dr Guillaume Baille 21 , Dr Kreisler 21 , Pr Jean-Pierre Pruvo 21 , Pr Leclerc 21 , Dr Renaud Lopes 21 , Dr Romain Viard 21 , Dr Gregory Kuchcinski 21 , Mr Julien Dumont 21 , Pr Kathy Dujardin 21 , Mme M Delliaux 21 , Mrs M Brion 21 , Dr Gustavo Touzet 21 , Pr Nicolas Reyns 21 , Pr Arnaud Delval 21 , Mrs Valerie Santraine 21 , Mrs Marie Pleuvret 21 , Mrs Nolwen Dautrevaux 21 , Mr Victor Laugeais 21 , Thavarak Ouk 21 , Camille Potey 21 , Celine Leclercq 21 , Elise Gers 21 , Jean-Christophe Corvol 22 , Marie-Vidailhet 22 , Elodie Hainque 22 , Marie-Laure Welter 22 , Lucette Lacomblez 22 , David Grabli 22 , Emmanuel Roze 22 , Yulia Worbe 22 , Cécile Delorme 22 , Hana You 22 , Jonas Ihle 22 , Raquel Guimeraes-Costa 22 , Florence Cormier-Dequaire 22 , Aurélie Méneret 22 , Andréas Hartmann 22 , Louise-Laure Mariani 22 , Stéphane Lehericy 22 , Virginie Czernecki 22 , Fanny Pineau 22 , Frédérique Bozon 22 , Camille Huiban 22 , Eve Benchetrit 22 , Carine Karachi 22 , Soledad Navarro 22 , Philippe Cornu 22 , Arlette Welaratne 22 , Carole Dongmo-Kenfack 22 , Lise Mantisi 22 , Nathalie Jarry 22 , Sophie Aix 22 , Carine Lefort 22 , Dr Tiphaine Rouaud 23 , Pr Philippe Damier 23 , Pr Pascal Derkinderen 23 , Dr Anne-Gaelle Corbille 23 , Dr Elisabeth Calvier-Auffray 23 , Mrs Laetitia Rocher 23 , Mrs Anne-Laure Deruet 23 , Dr Raoul Sylvie 23 , Dr Roualdes Vincent 23 , Mrs Le Dily Séverine 23 , Dr Ana Marques 24 , Dr Berangere Debilly 24 , Pr Franck Durif 24 , Dr Philippe Derost 24 , Dr Charlotte Beal 24 , Carine Chassain 24 , Laure Delaby 24 , Tiphaine Vidal 24 , Pr Jean Jacques Lemaire 24 , Isabelle Rieu 24 , Elodie Durand 24 , Pr Alexandre Eusebio 25 , Pr Jean-Philippe Azulay 25 , Dr Tatiana Witjas 25 , Dr Frédérique Fluchère 25 , Dr Stephan Grimaldi 25 , Pr Nadine Girard 25 , Eve Benchetrit 25 , Marie Delfini 25 , Dr Romain Carron 25 , Pr Jean Regis 25 , Dr Giorgio Spatola 25 , Camille Magnaudet 25 , Dr Ansquer Solène 26 , Dr Benatru Isabelle 26 , Dr Colin Olivier 26 , Pr Houeto Jl 26 , Pr Guillevin Remy 26 , Mrs Fradet Anne 26 , Mrs Anziza Manssouri 26 , Mrs Blondeau Sophie 26 , Dr Richard Philippe 26 , Dr Cam Philippe 26 , Dr Page Philippe 26 , Pr Bataille Benoit 26 , Mrs Rabois Emilie 26 , Mrs Guillemain Annie 26 , Dr Drapier Sophie 27 , Dr Frédérique Leh 27 , Dr Alexandre Bonnet 27 , Pr Marc Vérin 27 , Dr Jean-Christophe Ferré 27 , Mr Jean François Houvenaghel 27 , Pr Claire Haegelen 27 , Mrs Francoise Kestens 27 , Mrs Solenn Ory 27 , Pr Pierre Burbaud 28 , Dr Nathalie Damon-Perriere 28 , Pr Wassilios Meissner 28 , Pr Francois Tison 28 , Dr Stéphanie Bannier 28 , Dr Elsa Krim 28 , Pr Dominique Guehl 28 , Sandrine Molinier-Blossier 28 , Morgan Ollivier 28 , Marion Lacoste 28 , Nicolas Auzou 28 , Marie Bonnet 28 , Pr Emmanuel Cuny 28 , Dr Julien Engelhardt 28 , Olivier Branchard 28 , Clotilde Huet 28 , Julie Blanchard 28 , Pr Rascol Olivier 29 , Dr Christine Brefel Courbon 29 , Dr Fabienne Ory Magne 29 , Dr Marion Simonetta Moreau 29 , Pr Christophe Arbus 29 , Pr Fabrice Bonneville 29 , Dr Jean Albert Lotterie 29 , Marion Sarrail 29 , Charlotte Scotto d'Apollonia 29 , Pr Patrick Chaynes 29 , Pr François Caire 29 , Estelle Harroch 29 , Pr David Maltete 30 , Dr Romain Lefaucheur 30 , Dr Damien Fetter 30 , Dr Nicolas Magne 30 , Mrs Sandrine Bioux 30 , Mrs Maud Loubeyre 30 , Mrs Evangéline Bliaux 30 , Mrs Dorothée Pouliquen 30 , Pr Stéphane Derrey 30 , Mrs Linda Vernon 30 , Dr Frédéric Ziegler 30 , Mathieu Anheim 31 , Ouhaid Lagha-Boukbiza 31 , Christine Tranchant 31 , Odile Gebus 31 , Solveig Montaut 31 , S Kremer 31 , Nadine Longato 31 , Clélie Phillips 31 , Jimmy Voirin 31 , Marie des Neiges Santin 31 , Dominique Chaussemy 31 , Dr Amaury Mengin 31 , Dr Caroline Giordana 32 , Dr Claire Marsé 32 , Lydiane Mondot 32 , Bruno Giordana 32 , Robin Kardous 32 , Bernadette Bailet 32 , Héloise Joly 32 , Denys Fontaine 32 , Dr Aurélie Leplus 32 , Amélie Faustini 32 , Vanessa Ferrier 32 , Pr Pierre Krystkowiak 33 , Dr Mélissa Tir 33 , Pr Jean-Marc Constans 33 , Sandrine Wannepain 33 , Audrey Seling 33 , Dr Michel Lefranc 33 , Stéphanie Blin 33 , Béatrice Schuler 33 , Pr Stephane Thobois 34 , Dr Teodor Danaila 34 , Dr Chloe Laurencin 34 , Pr Yves Berthezene 34 , Dr Roxana Ameli 34 , Helene Klinger 34 , Dr Gustavo Polo 34 , Patrick Mertens 34 , A Nunes 34 , Elise Metereau 34 , Dr Lucie Hopes 35 , Dr Solène Frismand 35 , Dr Emmanuelle Schmitt 35 , Mrs Mylène Meyer 35 , Mrs Céline Dillier 35 , Pr Sophie Colnat 35 , Mrs Anne Chatelain 35 , Dr Jean- Philippe Brandel 36 , Dr Cécile Hubsch 36 , Dr Patte Karsenti 36 , Dr Marie Lebouteux 36 , Dr Marc Ziegler 36 , Dr Christine Delmaire 36 , Dr Julien Savatowky 36 , Mrs Juliette Vrillac 36 , Mrs Claire Nakache 36 , Dr Vincent D'Hardemare 36 , Mr Lhaouas Belamri 36 , Dr Valérie Mesnage 37 , Dr Cécilia Bonnet 37 , Dr Jarbas Correa Lino Jr 37 , Dr Camille Decrocq 37 , Dr Anne Boulin 37 , Mrs Inès Barre 37 , Mrs Jordane Manouvrier 37 , Dr Bérénice Gardel 37 , Pr Béchir Jarraya 37 , Mrs Catherine Ziz 37 , Mrs Lydie Prette 37 , Mr Hassen Douzane 37 , David Gay 38 , Robin Bonicel 38 , Fouzia El Mountassir 38 , Clara Fischer 38 , Jean-François Mangin 38 , Marie Chupin 38 , Yann Cointepas 38 , Bertrand Accart 39 , Patrick Gelé 39 , Florine Fievet 39 , Matthieu Chabel 39 , Virginie Derenaucourt 39 , Loïc Facon 39 , Yanick Tchantchou Njosse 39 , Dominique Deplanque 39 , Alain Duhamel 40 , Lynda Djemmane 40 , Florence Duflot 40
Affiliations
- 1 Toulouse NeuroImaging Center, University of Toulouse, Inserm, UPS, France. Electronic address: mathilde.boussac@inserm.fr.
- 2 Psychiatry Department of the University Hospital of Toulouse, CHU Purpan, Toulouse, France.
- 3 Service de neurologie, Centre Hospitalier de Brive-la-Gaillarde, France; Centre Expert Parkinson, CHU de Limoges, France.
- 4 Service de neurologie C - Hôpital Neurologique - 59 boulevard Pinel 69003 Lyon - Hospices Civils de Lyon, France.
- 5 Aix Marseille Université, AP-HM, Hôpital de La Timone, Service de Neurologie et Pathologie du Mouvement, and UMR CNRS 7289, Institut de Neuroscience de La Timone, NS-PARK/FCRIN Network, Marseille, France.
- 6 Département de Neurologie, Hôpital Pitié-Salpêtrière, AP-HP, Paris, France; et Faculté de Médecine de Sorbonne Université, UMR S 1127, Inserm U 1127, and CNRS UMR 7225, and Institut du Cerveau, F-75013, Paris, France.
- 7 Department of Neurology, Hôpital Fondation Rothschild, Paris, France.
- 8 Toulouse NeuroImaging Center, University of Toulouse, Inserm, UPS, France; Department of Clinical Pharmacology and Neurosciences, Parkinson Expert Center, Clinical Investigation Center CIC1436, University Hospital of Toulouse, NeuroToul COEN (Center of Excellence in Neurodegeneration), Toulouse, NS-PARK/FCRIN Network, France.
- 9 Department of Clinical Pharmacology and Neurosciences, Parkinson Expert Center, Clinical Investigation Center CIC1436, University Hospital of Toulouse, NeuroToul COEN (Center of Excellence in Neurodegeneration), Toulouse, NS-PARK/FCRIN Network, France.
- 10 Department of Medical Pharmacology, Neurology and Movement Disorders Department, Referent Center of Parkinson's disease, CHU of Lille, Univ. Lille Neuroscience & Cognition, Inserm, UMR-S1172, Licend, Lille, NS-PARK/FCRIN Network, France.
- 11 Service de Neurologie, Unité des Mouvements Anormaux, Foch Hospital, Suresnes, France; Université de Versailles Paris-Saclay, INSERM U992, CEA Neurospin, Saclay, France.
- 12 Department of Neurology, Rouen University Hospital and University of Rouen, France; INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Mont-Saint-Aignan, France.
- 13 Service de neurologie, CHU Rennes, CIC INSERM, 1414, Rennes, France.
- 14 Université Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand University Hospital, Neurology department, France.
- 15 Institut des Maladies neurodégénératives, Pôle des neurosciences cliniques, CHU Bordeaux, France; Service de neurophysiologie clinique de l'enfant et de l'adulte, Pôle des neurosciences cliniques, CHU Bordeaux, France.
- 16 Service de Neurologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France; Institut de Génétique et de Biologie Moléculaire et Cellulaire, INSERM-U964/CNRSUMR7104/Université de Strasbourg, Illkirch-Graffenstaden, France; Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Strasbourg, France.
- 17 Neurology Department of the University Hospital of Nancy, CHRU de Nancy, Nancy, France.
- 18 CHU Nice, Department of Psychiatry and Psychotherapy, Nice, France.
- 19 Department of Neurology, Department of Neurosurgery, Expert Centre for Parkinson's disease, Amiens University Hospital, EA 4559 Laboratoire de Neurosciences Fonctionnelles et Pathologie (LNFP) Université de Picardie Jules Verne, University of Picardy Jules Verne (UPJV), NS-PARK/FCRIN Network, Amiens, France.
- 20 Department of Neurology, Expert Centre for Parkinson's Disease, University Hospital of Nantes, Nantes, France.
- 21 Lille University Hospital, France.
- 22 AP-HP, Paris, France.
- 23 Nantes University Hospital, France.
- 24 Clermont-Ferrand University Hospital, France.
- 25 AP-HM, Marseille, France.
- 26 Poitiers University Hospital, France.
- 27 Rennes University Hospital, France.
- 28 Bordeaux University Hospital, France.
- 29 Toulouse University Hospital, France.
- 30 Rouen University Hospital, France.
- 31 Strasbourg University Hospital, France.
- 32 Nice University Hospital, France.
- 33 Amiens University Hospital, France.
- 34 Lyon University Hospital, France.
- 35 Nancy University Hospital, France.
- 36 Rotschild fondation of Paris, France.
- 37 Foch Hospital of Paris-Saclay University, France.
- 38 CATI, MRI acquisition Management, Preprocessing and data Management, France.
- 39 CRB of Lille (Center of Biological Resources), France.
- 40 Data Management of Lille, France.
- PMID: 36030666
- DOI: 10.1016/j.parkreldis.2022.08.004
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Abstract
Introduction: There is a growing interest in personality evaluation in Parkinson's disease (PD), following observations of specific temperaments in PD patients. Therefore, our objective was to evaluate personality dimensions from the Temperament and Character Inventory (TCI) in a cohort of fluctuating PD patients considered for deep brain stimulation.
Methods: Fluctuating PD patients from the PREDISTIM cohort were included. Description of TCI dimensions and comparison with a French normative cohort were performed. Pearson correlations between TCI dimensions and motor, behavioral and cognitive variables were investigated. Structural and internal consistency analysis of the TCI were further assessed.
Results: The 570 PD patients presented significant higher scores in Harm Avoidance, Reward Dependence, Persistence, Self-Directedness and Cooperativeness and significant lower scores in Self-Transcendence compared to the French normative cohort; only Novelty Seeking scores were not different. Harm Avoidance and Self-directedness scores were correlated with PDQ-39 total, HAMD, HAMA scores, and anxiolytic/antidepressant treatment. Novelty Seeking scores were correlated with impulsivity. Pearson correlations between TCI dimensions, principal component analysis of TCI sub-dimensions and Cronbach's alpha coefficients showed adequate psychometric proprieties.
Conclusion: The TCI seems to be an adequate tool to evaluate personality dimensions in PD with good structural and internal consistencies. These fluctuating PD patients also have specific personality dimensions compared to normative French population. Moreover, Harm Avoidance and Self-Directedness scores are associated with anxio-depressive state or quality of life and, and Novelty Seeking scores with impulsivity.
Trial registration: ClinicalTrials.gov NCT02360683.
Keywords: Fluctuating PD patients; Parkinson's disease; Personality; Temperament and character inventory.
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