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. 2022 Oct:175:193-196.
doi: 10.1016/j.radonc.2022.08.024. Epub 2022 Aug 27.

Changes in Radical Levels as a Cause for the FLASH effect: Impact of beam structure parameters at ultra-high dose rates on oxygen depletion in water

Jeannette Jansen  1 , Elke Beyreuther  2 , Daniel García-Calderón  3 , Leonhard Karsch  4 , Jan Knoll  3 , Jörg Pawelke  4 , Michael Schürer  5 , Joao Seco  6
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Changes in Radical Levels as a Cause for the FLASH effect: Impact of beam structure parameters at ultra-high dose rates on oxygen depletion in water

Jeannette Jansen et al. Radiother Oncol. 2022 Oct.

Abstract

The influence of different average and bunch dose rates in electron beams on the FLASH effect was investigated. The present study measures O2 content in water at different beam pulse patterns and finds strong correlation with biological data, strengthening the hypothesis of radical-related mechanisms as a reason for the FLASH effect.

Keywords: FLASH effect; Oxygen depletion; Pulse structure; Radical reduction.

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