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Comment
. 2022 Aug 28;7(1):299.
doi: 10.1038/s41392-022-01066-z.

A new insight for stem cell therapy: apoptotic stem cells as a key player

Yuhe Huang  1 , Ziyi Bai  1 , Kang Zhang  2
Affiliations
Comment

A new insight for stem cell therapy: apoptotic stem cells as a key player

Yuhe Huang et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests. Kang Zhang is one of the Editors-in-Chief of Signal Transduction and Targeted Therapy, but he has not been involved in the process of the manuscript handling.

Figures

Fig. 1
Fig. 1
Apoptosis is necessary for immunomodulatory functions of MSCs therapy. After MSC injection, apoptotic MSCs were found in the lung. Alveolar macrophages (AMs) engulf the apoptotic cells and release cytokines to exert immune effects, reducing inflammation. In the liver, dead MSCs (DMSCs) release cytokines, of which, the released phosphatidylserine (PS) recruits monocyte-derived macrophages (MoMF) to release IL-10, acting on natural killer cells and neutrophils to exert an immune effect. Created with BioRender.com
See this image and copyright information in PMC

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References

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