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Review
. 2022 Aug 12:13:969447.
doi: 10.3389/fimmu.2022.969447. eCollection 2022.

Hyperthermia combined with immune checkpoint inhibitor therapy in the treatment of primary and metastatic tumors

Ximing Yang  1 , Miaozhi Gao  1 , Runshi Xu  1 , Yangyang Tao  1 , Wang Luo  1 , Binya Wang  1 , Wenliang Zhong  1   2 , Lan He  3   4 , Yingchun He  1   2   3
Affiliations
Review

Hyperthermia combined with immune checkpoint inhibitor therapy in the treatment of primary and metastatic tumors

Ximing Yang et al. Front Immunol. .

Abstract

According to the difference in temperature, thermotherapy can be divided into thermal ablation and mild hyperthermia. The main advantage of thermal ablation is that it can efficiently target tumors in situ, while mild hyperthermia has a good inhibitory effect on distant metastasis. There are some similarities and differences between the two therapies with respect to inducing anti-tumor immune responses, but neither of them results in sustained systemic immunity. Malignant tumors (such as breast cancer, pancreatic cancer, nasopharyngeal carcinoma, and brain cancer) are recurrent, highly metastatic, and highly invasive even after treatment, hence a single therapy rarely resolves the clinical issues. A more effective and comprehensive treatment strategy using a combination of hyperthermia and immune checkpoint inhibitor (ICI) therapies has gained attention. This paper summarizes the relevant preclinical and clinical studies on hyperthermia combined with ICI therapies and compares the efficacy of two types of hyperthermia combined with ICIs, in order to provide a better treatment for the recurrence and metastasis of clinically malignant tumors.

Keywords: combined therapy; immune checkpoint inhibitor; malignant tumor; mild hyperthermia; thermal ablation.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Partial mechanism diagram of hyperthermia combined with ICIs on tumor microenvironment. Created with BioRender.com.
See this image and copyright information in PMC

References

    1. Lentz RW, Colton MD, Mitra SS, Messersmith WA. Innate immune checkpoint inhibitors: The next breakthrough in medical oncology? Mol Cancer Ther (2021) 20(6):961–74. doi: 10.1158/1535-7163.MCT-21-0041 - DOI - PMC - PubMed
    1. Petitprez F, Meylan M, de Reynies A, Sautes-Fridman C, Fridman WH. The tumor microenvironment in the response to immune checkpoint blockade therapies. Front Immunol (2020) 11:784. doi: 10.3389/fimmu.2020.00784 - DOI - PMC - PubMed
    1. Dolina JS, Van Braeckel-Budimir N, Thomas GD, Salek-Ardakani S. CD8(+) T cell exhaustion in cancer. Front Immunol (2021) 12:715234. doi: 10.3389/fimmu.2021.715234 - DOI - PMC - PubMed
    1. Zhang Z, Lu M, Qin Y, Gao W, Tao L, Su W, et al. Neoantigen: A new breakthrough in tumor immunotherapy. Front Immunol (2021) 12:672356. doi: 10.3389/fimmu.2021.672356 - DOI - PMC - PubMed
    1. Liu S, Galat V, Galat Y, Lee YKA, Wainwright D, Wu J. NK cell-based cancer immunotherapy: from basic biology to clinical development. J Hematol Oncol (2021) 14(1):7. doi: 10.1186/s13045-020-01014-w - DOI - PMC - PubMed

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