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Review
. 2022 Aug 12:12:962702.
doi: 10.3389/fonc.2022.962702. eCollection 2022.

Molecular determinants of outcomes in meningiomas

John Lynes  1   2 , Gabriel Flores-Milan  1   2 , Sebastian Rubino  1   2 , John Arrington  3 , Robert Macaulay  4 , James K C Liu  1   2 , Andre Beer-Furlan  1   2 , Nam D Tran  1   2 , Michael A Vogelbaum  1   2 , Arnold B Etame  1   2
Affiliations
Review

Molecular determinants of outcomes in meningiomas

John Lynes et al. Front Oncol. .

Abstract

Meningiomas are the most common intracranial primary tumor in adults. Surgery is the predominant therapeutic modality for symptomatic meningiomas. Although the majority of meningiomas are benign, there exists a subset of meningiomas that are clinically aggressive. Recent advances in genetics and epigenetics have uncovered molecular alterations that drive tumor meningioma biology with prognostic and therapeutic implications. In this review, we will discuss the advances on molecular determinants of therapeutic response in meningiomas to date and discuss findings of targeted therapies in meningiomas.

Keywords: brain tumor; epigenetics; genetics; meningiomas; molecular classification; outcomes; targeted therapy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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