Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Aug 19:2022:7366432.
doi: 10.1155/2022/7366432. eCollection 2022.

Application Value of Metagenomics Next-Generation Sequencing (mNGS) in Detection of Mucormycosis after Chemotherapy in Childhood Acute Leukemia

Wenzi Li  1 , Hua Zhu  2 , Li Wen  1 , Meijie Quan  1 , Li Wang  1
Affiliations

Application Value of Metagenomics Next-Generation Sequencing (mNGS) in Detection of Mucormycosis after Chemotherapy in Childhood Acute Leukemia

Wenzi Li et al. Evid Based Complement Alternat Med. .

Retraction in

Abstract

Objective: To analyze the application of macrogenomics next-generation sequencing (mNGS) in the detection of postchemotherapy trichomoniasis cases in children with acute leukemia.

Methods: To retrospectively analyze the clinical data of 7 patients with acute leukemia combined with trichomoniasis after chemotherapy in the department of hematology and oncology of Hebei Children's Hospital, and to summarize the characteristics of their postchemotherapy clinical data, diagnostic and therapeutic processes, and outcomes.

Results: Among the 7 children, 6 cases had acute lymphoblastic leukemia and 1 case had acute myeloid leukemia. mNGS detected trichoderma infection, including 1 case of pulmonary cerebral type and 6 cases of pulmonary type. After treatment, 1 case died, 2 cases were cured, and 4 cases improved.

Conclusion: The clinical manifestations of trichomoniasis after combined chemotherapy in pediatric acute leukemia lack specificity. Early application of the mNGS assay is of great value.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no conflicts of interest regarding this work.

Figures

Figure 1
Figure 1
Immunofluorescence of fungal hyphae.
Figure 2
Figure 2
Hexamine silver staining showed that the fungal hyphae were short black rod-like structures.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Inaba H., Mullighan C. G. Pediatric acute lymphoblastic leukemia. Haematologica . 2020;105(11):p. 2524. - PMC - PubMed
    1. Sipsas N. V., Gamaletsou M. N., Anastasopoulou A. Therapy of mucormycosis. Journal of Fungi . 2018;4(3):p. 90. - PMC - PubMed
    1. Jeong W., Keighley C., Wolfe R., et al. The epidemiology and clinical manifestations of mucormycosis: a systematic review and meta-analysis of case reports. Clinical Microbiology and Infections . 2019;25(1):26–34. doi: 10.1016/j.cmi.2018.07.011. - DOI - PubMed
    1. Al-Azab A. M., Zaituon A. A., Al-Ghamdi K. M., Al-Galil F. M. A. Surveillance of dengue fever vector Aedes aegypti in different areas in Jeddah city Saudi Arabia. Advances in Animal and Veterinary Sciences . 2022;10(2):348–353. doi: 10.3390/jof7080636. - DOI
    1. Cornely O. A., Alastruey-Izquierdo A., Arenz D., et al. Global guideline for the diagnosis and management of mucormycosis: an initiative of the European confederation of medical mycology in cooperation with the mycoses study group education and Research consortium. The Lancet Infectious Diseases . 2019;19(12):e405–e421. doi: 10.1016/s1473-3099(19)30312-3. - DOI - PMC - PubMed

Publication types

LinkOut - more resources