Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Aug 10:13:950162.
doi: 10.3389/fgene.2022.950162. eCollection 2022.

A review on the role of miRNA-324 in various diseases

Sepideh Kadkhoda  1 , Bashdar Mahmud Hussen  2   3 , Solat Eslami  4   5 , Soudeh Ghafouri-Fard  6
Affiliations
Review

A review on the role of miRNA-324 in various diseases

Sepideh Kadkhoda et al. Front Genet. .

Abstract

Recent studies have revealed important functions of several microRNAs (miRNAs) in the pathogenesis of human diseases. miR-324 is an example of miRNAs with crucial impacts on the pathogenesis of a wide range of disorders. Gene ontology studies have indicated possible role of miR-324 in responses of cells to the leukemia inhibitory factor, long-term synaptic potentiation, positive regulation of cytokines production and sensory perception of sound. In human, miR-324 is encoded by MIR324 gene which resides on chromosome 17p13.1. In the current manuscript, we provide a concise review of the role of miR-324 in the pathogenesis of cancers as well as non-cancerous conditions such as aneurysmal subarachnoid hemorrhage, diabetic nephropathy, epilepsy, pulmonary/renal fibrosis, ischemic stroke and ischemia reperfusion injuries. Moreover, we summarize the role of this miRNA as a prognostic marker for malignant disorders.

Keywords: biomarker; cancer; expreesion; miR-324; prognostic.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Role of miR-324 in progression of cervical cancer.
FIGURE 2
FIGURE 2
Role of miR-324 in progression of colorectal cancer.
FIGURE 3
FIGURE 3
Role of miR-324 in progression of gastric cancer.
FIGURE 4
FIGURE 4
Role of miR-324 in progression of brain tumors.
FIGURE 5
FIGURE 5
Role of miR-324 in progression of hepatocellular carcinoma.
FIGURE 6
FIGURE 6
Role of miR-324 in progression of nasopharyngeal cancer.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Abiusi E., Infante P., Cagnoli C., Lospinoso Severini L., Pane M., Coratti G., et al. (2021). SMA-miRs (miR-181a-5p, -324-5p, and -451a) are overexpressed in spinal muscular atrophy skeletal muscle and serum samples. eLife 1, e68054. 10.7554/eLife.68054 - DOI - PMC - PubMed
    1. Balakathiresan N. S., Chandran R., Bhomia M., Jia M., Li H., Maheshwari R. K., et al. (2014). Serum and amygdala microRNA signatures of posttraumatic stress: Fear correlation and biomarker potential. J. Psychiatr. Res. 57, 65–73. 10.1016/j.jpsychires.2014.05.020 - DOI - PubMed
    1. Cao L., Xie B., Yang X., Liang H., Jiang X., Zhang D., et al. (2015). MiR-324-5p suppresses hepatocellular carcinoma cell invasion by counteracting ECM degradation through post-transcriptionally downregulating ETS1 and SP1. PloS one 10 (7), e0133074. 10.1371/journal.pone.0133074 - DOI - PMC - PubMed
    1. Chen N., Wang Z., Yang X., Geng D., Fu J., Zhang Y., et al. (2021). Integrated analysis of competing endogenous RNA in esophageal carcinoma. J. Gastrointest. Oncol. 12 (1), 11–27. 10.21037/jgo-20-615 - DOI - PMC - PubMed
    1. Chen Y., Fan Z., Wu Q. (2021). Dexmedetomidine improves oxygen-glucose deprivation/reoxygenation (OGD/R) -induced neurological injury through regulating SNHG11/miR-324-3p/VEGFA axis. Bioengineered 12 (1), 4794–4804. 10.1080/21655979.2021.1957071 - DOI - PMC - PubMed

LinkOut - more resources