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. 2022 Mar-Apr;119(2):115-121.

Biologic Joint Restoration: A Translational Research Success Story

James L Cook  1 , James P Stannard  2 , Aaron M Stoker  3 , Kylee Rucinski  3 , Brett D Crist  4 , Cristi R Cook  3 , Cory Crecelius  3 , Matthew J Smith  5 , Renee Stucky  3
Affiliations

Biologic Joint Restoration: A Translational Research Success Story

James L Cook et al. Mo Med. 2022 Mar-Apr.

Abstract

Treatment options that result in consistently successful outcomes for young and active patients with joint disorders are needed. This article summarizes two decades of rigorous research using a bedside-to-bench- to-bedside translational approach based on the One Health - One Medicine concept that culminated in successful clinical use of biologic joint restoration options for treatment of knee, hip, ankle, and shoulder problems in this growing patient population.

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Conflict of interest statement

Disclosure JLC: Arthrex: paid consultant, presenter or speaker, and research support; Bioventus: paid consultant; Coulter Foundation and DePuy: research grants, GE Healthcare: research support; Journal of Knee Surgery: rditorial or governing board; Merial: research support; Midwest Transplant Network: board or committee member; Musculoskeletal Transplant Foundation: board or committee member, IP royalties and research support; National Institutes of Health (NIAMS and NICHD): research support; Purina: research support; Thieme: publishing royalties, financial or material support; Trupanion: paid consultant; and U.S. Department of Defense: research support. JPS: DePuy, Orthopedica Designs North America, and Smith and Nephew: paid consultant; National Institutes of Health: research grant; American Orthopaedic Association: board or committee member; AO Foundation: board or committee member; AO North America: board or committee member; Journal of Knee Surgery: editorial or governing board; Mid-America Orthopaedic Association: board or committee member; Thieme: publishing royalties, financial, or material support; and U.S. Department of Defense: research support. MJS: Arthrex, Inc. and Wright Medical Technology: research grants; DePuy: paid presenter; Ignite Orthopedics: IP royalties, and stock/stock option. AMS: Musculoskeletal Transplant Foundation: IP royalties. CC: Arthrex, Inc., CONMED Linvatec, and the Musculoskeletal Transplant Foundation: paid consultant; Zimmer: research grant. BDC: KCI: paid consultant; Orthopaedic Implant Company and RomTech: stock/stock options; Springer: publishing royalties, financial, or material support; AO Trauma North America: board or committee member; Globus Medical: IP royalties; International Geriatric Fracture Society: board or committee member; Journal of Hip Preservation: editorial or governing board; Journal of Orthopaedic Trauma: editorial or governing board; Orthopaedic Trauma Association: board or committee member; Osteocentric: unpaid consultant; SLACK Incorporated: editorial or governing board; Synthes: paid consultant; research support.

Figures

Figure 1
Figure 1
University of Missouri’s One Health-One Medicine Translational Approach for Addressing Limitations to Successful Biologic Joint Restoration
Figure 2
Figure 2
Representative Intraoperative Images of MOPS-preserved Osteochondral Allograft Transplantation for Complex Biologic Joint Restoration in the Knee, Hip, Ankle, and Shoulder of Patients with Large Symptomatic Articular Defects.
None
See this image and copyright information in PMC

References

    1. Hunter W. Of the structure and diseases of articulating cartilage. Philosophical Transactions of the Royal Society of Londonfc. 42(1743):514–521.
    1. Witjes S, van Geenen RCI, Koenraadt KLM, et al. Expectations of younger patients concerning activities after knee arthroplasty: are we asking the right questions? Qual Life Res. 2017;26(2):403–417. doi: 10.1007/s11136-016-1380-9. - DOI - PMC - PubMed
    1. Bayliss LE, Culliford D, Monk AP, et al. The effect of patient age at intervention on risk of implant revision after total replacement of the hip or knee: a population-based cohort study. Lancet. 2017;389(10077):1424–1430. doi: 10.1016/S0140-6736(17)30059-4. - DOI - PMC - PubMed
    1. Santaguida PL, Hawker GA, Hudak PL, et al. Patient characteristics affecting the prognosis of total hip and knee joint arthroplasty: a systematic review. Can J Surg. 2008;51(6):428–436. - PMC - PubMed
    1. Walker-Santiago R, Tegethoff JD, Ralston WM, Keeney JA. Revision Total Knee Arthroplasty in Young Patients: Higher Early Reoperation and Rerevision. J Arthroplasty. 2021;36(2):653–656. doi: 10.1016/j.arth.2020.08.052. - DOI - PubMed

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