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. 2023 Jan 15;207(2):208-211.
doi: 10.1164/rccm.202204-0766LE.

Peripheral Blood Telomere Attrition in Persons at Risk for Familial Pulmonary Fibrosis

Affiliations

Peripheral Blood Telomere Attrition in Persons at Risk for Familial Pulmonary Fibrosis

Margaret L Salisbury et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
The relationship between personal and familial telomerase pathway rare variant (RV) carrier status and peripheral blood telomere length at baseline and during follow-up. (A) The data distribution for %-eMTL at enrollment, stratified by individual and family telomerase RV carrier status. (B) The data distribution for the annualized change in MTL (in kb) stratified by individual and family telomerase RV carrier status. The data are shown as mean (diamond), range (whiskers), first and third quartiles (lower and upper box lines, respectively), and median (center box line). The individual data points are green circles. %-eMTL = percent of expected mean telomere length; MTL = mean telomere length.

References

    1. Armanios M, Chen JL, Chang YP, Brodsky RA, Hawkins A, Griffin CA, et al. Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita. Proc Natl Acad Sci USA . 2005;102:15960–15964. - PMC - PubMed
    1. Armanios MY, Chen JJ, Cogan JD, Alder JK, Ingersoll RG, Markin C, et al. Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med . 2007;356:1317–1326. - PubMed
    1. Alder JK, Chen JJ, Lancaster L, Danoff S, Su SC, Cogan JD, et al. Short telomeres are a risk factor for idiopathic pulmonary fibrosis. Proc Natl Acad Sci USA . 2008;105:13051–13056. - PMC - PubMed
    1. Cronkhite JT, Xing C, Raghu G, Chin KM, Torres F, Rosenblatt RL, et al. Telomere shortening in familial and sporadic pulmonary fibrosis. Am J Respir Crit Care Med . 2008;178:729–737. - PMC - PubMed
    1. Cogan JD, Kropski JA, Zhao M, Mitchell DB, Rives L, Markin C, et al. Rare variants in RTEL1 are associated with familial interstitial pneumonia. Am J Respir Crit Care Med . 2015;191:646–655. - PMC - PubMed

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