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. 2022 Oct:218:142-144.
doi: 10.1016/j.thromres.2022.08.005. Epub 2022 Aug 11.

Preexisting anti-PF4 antibodies are not further triggered upon vaccination with SARS-CoV-2 vector vaccines in a cohort of 400 health care workers

Wagner Angelika  1 , Garner-Spitzer Erika  1 , Kundi Michael  2 , Stockinger Hannes  3 , Pabinger Ingrid  4 , Eichinger-Hasenauer Sabine  4 , Quehenberger Peter  5 , Wagner Oswald  5 , Wiedermann Ursula  6 , Grabmeier-Pfistershammer Katharina  7
Affiliations

Preexisting anti-PF4 antibodies are not further triggered upon vaccination with SARS-CoV-2 vector vaccines in a cohort of 400 health care workers

Wagner Angelika et al. Thromb Res. 2022 Oct.
No abstract available

Keywords: Anti-PF4 antibodies; COVID-19 vector vaccine ChAdOx1; Spike subunit 1-specific antibodies.

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Conflict of interest statement

Declaration of competing interest AW: support for attending ECCMID 2022 conference (Astra Zeneca); EGS: none, MK: investigator initiated research contract (Pfizer), consulting fees (Valneva, Bluesky vaccines Escientia), payment for lectures/presentations (Bristol – Myers Squibb), payment for expert testimony (Lundy, Lundy, Soileau & South, LLP); HS: none; IP: none; SE: none; PQ: none; OW: none; UW: none; KGP: none.

Figures

Fig. 1
Fig. 1
Anti-PF4 antibody values before and after the first dose of ChAdOx1 and the correlation with SARS-CoV-2 S1-specific IgG values. (A) The anti-PF4 IgG values measured before (day 0) and 21 days after the first dose of ChAdOx1 are expressed in OD. The dotted line represents cut-off for positive anti-PF4 IgG values at OD 0.5. (B) Anti-PF4 antibody and SARS-CoV-2 antibody values were correlated upon measuring of sera taken from the vaccinees either immediately before vaccination with ChAdOx1 (A) and 21 days after the first dose of ChAdOx1 (B). The dotted lines represent the cut-off for positive anti-PF4 antibody values at OD 0.5 and the black lines represent the cut-off for positive SARS-CoV-2 S1-specific IgG at 35.2 BAU/ml.
See this image and copyright information in PMC

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