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Review
. 2022 Dec;215(Pt 1):114131.
doi: 10.1016/j.envres.2022.114131. Epub 2022 Aug 28.

An updated review of the scientific literature on the origin of SARS-CoV-2

Jose L Domingo  1
Affiliations
Review

An updated review of the scientific literature on the origin of SARS-CoV-2

Jose L Domingo. Environ Res. 2022 Dec.

Abstract

More than two and a half years have already passed since the first case of COVID-19 was officially reported (December 2019), as well as more than two years since the WHO declared the current pandemic (March 2020). During these months, the advances on the knowledge of the COVID-19 and SARS-CoV-2, the coronavirus responsible of the infection, have been very significant. However, there are still some weak points on that knowledge, being the origin of SARS-CoV-2 one of the most notorious. One year ago, I published a review focused on what we knew and what we need to know about the origin of that coronavirus, a key point for the prevention of potential future pandemics of a similar nature. The analysis of the available publications until July 2021 did not allow drawing definitive conclusions on the origin of SARS-CoV-2. Given the great importance of that issue, the present review was aimed at updating the scientific information on that origin. Unfortunately, there have not been significant advances on that topic, remaining basically the same two hypotheses on it. One of them is the zoonotic origin of SARS-CoV-2, while the second one is the possible leak of this coronavirus from a laboratory. Most recent papers do not include observational or experimental studies, being discussions and positions on these two main hypotheses. Based on the information here reviewed, there is not yet a definitive and well demonstrated conclusion on the origin of SARS-CoV-2.

Keywords: COVID-19; Hosts; Laboratory leak; SARS-CoV-2; Zoonotic origin.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

References

    1. Bhattacharya S., Tilak R., Bose C., Sinha S. Is the origin and emergence of SARS-CoV-2 ingenuous? J. Commun. Dis. 2021;53:232–235.
    1. Bloom J.D., Chan Y.A., Baric R.S., Bjorkman P.J., Cobey S., Deverman B.E., Fisman D.N., Gupta R., Iwasaki A., Lipsitch M., Medzhitov R., Neher R.A., Nielsen R., Patterson N., Stearns T., van Nimwegen E., Worobey M., Relman D.A. Investigate the origins of COVID-19. Science. 2021;372:694. - PMC - PubMed
    1. Borsetti A., Scarpa F., Maruotti A., Divino F., Ceccarelli G., Giovanetti M., Ciccozzi M. The unresolved question on COVID-19 virus origin: the three cards game? J. Med. Virol. 2022;94:1257–1260. - PubMed
    1. Cattaneo A.M. Reviewing findings on the polypeptide sequence of the SARS-CoV-2 S-protein to discuss the origins of the virus. Future Virol. 2022 doi: 10.2217/fvl-2021-0233. - DOI - PMC - PubMed
    1. Chakraborty C., Bhattacharya M., Nandi S.S., Mohapatra R.K., Dhama K., Agoramoorthy G. Appearance and re-appearance of zoonotic disease during the pandemic period: long-term monitoring and analysis of zoonosis is crucial to confirm the animal origin of SARS-CoV-2 and monkeypox virus. Vet. Q. 2022;42:119–124. - PMC - PubMed