SARS-CoV-2 infection showing signs of cerebral sinus vein thrombosis in the infantile period

Abstract

The clinical manifestations of SARS-CoV-2 infection mainly involve the respiratory system. However, there is increasing evidence that this virus can affect other organs, causing a wide range of clinical symptoms. This is the report of a 40-day-old patient who presented with sepsis and had no risk factors other than SARS-CoV-2 infection, whose radiological findings were compatible with cerebral sinus vein thrombosis.

Keywords: COVID-19; COVID-19, Coronavirus disease 2019; CSF, Cerebrospinal fluid; CT, Computed tomography; Coagulopathy; GBS, Guillain-Barré syndrome; HIV, Human Immunodeficiency Virus; LMWH, Low-molecular-weight heparin; MIS-C, Pediatric multisystem inflammatory syndrome; MTHFR, Metilen Tetra Hidro Folat Redüktaz; Neurological symptom; RT-PCR, Reverse transcriptase - polymerase chain reaction; SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2; Thrombosis; UFH, Unfractionated heparin.

Fig. 1

Axial (A) and coronal cross-section (B) non-contrast CT scans: broadened and excessively dense appearance of the left and right transverse sinuses (arrows) compatible with thrombosis.

Fig. 2

T1-weighted contrast sagittal (A) and axial (B) MR images, superior sagittal and right transverse sinus thrombosis (arrows) appearing as filling defects.

Fig. 3

Three-dimensional phase-contrast MR angiography MIP images; occlusion of the right transverse sinus and jugular vein due to thrombosis and filling defect in distal part of superior sagittal sinus.