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Editorial
. 2022 Oct;14(19):1341-1343.
doi: 10.4155/fmc-2022-0178. Epub 2022 Aug 30.

γ-Secretase as a drug target for familial Alzheimer's disease: the road less traveled

Michael S Wolfe  1
Affiliations
Editorial

γ-Secretase as a drug target for familial Alzheimer's disease: the road less traveled

Michael S Wolfe. Future Med Chem. 2022 Oct.
No abstract available

Keywords: amyloid; mutations; proteolysis.

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References

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    1. Wolfe MS. Dysfunctional γ-secretase in familial Alzheimer's disease. Neurochem. Res. 44(1), 5–11 (2019). - PMC - PubMed
    1. Zhou R, Yang G, Guo X, Zhou Q, Lei J, Shi Y. Recognition of the amyloid precursor protein by human γ-secretase. Science 363(6428), eaaw0930 (2019). - PubMed
    1. Takami M, Nagashima Y, Sano Y et al. γ-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment. J. Neurosci. 29(41), 13042–13052 (2009). - PMC - PubMed

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