Nature versus nurture contribution to prostate cancer risk
- PMID: 36042289
- PMCID: PMC10179443
- DOI: 10.1038/s41585-022-00650-w
Nature versus nurture contribution to prostate cancer risk
Abstract
Genetics has a role in predisposition towards prostate cancer, and an accurate prediction of prostate cancer risk can be made using polygenic risk scores. New evidence suggests that this risk is modifiable through lifestyle changes, but only in men at a high genetic risk of developing prostate cancer.
Conflict of interest statement
Competing interests
The authors declare no competing interests.
Comment on
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A Healthy Lifestyle in Men at Increased Genetic Risk for Prostate Cancer.Eur Urol. 2023 Apr;83(4):343-351. doi: 10.1016/j.eururo.2022.05.008. Epub 2022 May 28. Eur Urol. 2023. PMID: 35637041 Free PMC article.
References
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- Wilson KM & Mucci LA in Prostate Cancer: Cellular and Genetic Mechanisms of Disease Development and Progression 2nd edn Vol. 1210 (eds Dehm SM & Tindall DJ) 1–27 (Springer, 2019).
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- World Cancer Research Fund & American Institute for Cancer Research. Diet, Nutrition, Physical Activity and Cancer: a Global Perspective. Continuous Update Project Expert Report (World Cancer Research Fund International, 2018).
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