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Review
. 2022 Nov;83(7):1534-1554.
doi: 10.1002/ddr.21990. Epub 2022 Aug 30.

Beta-lactam resistance and the effectiveness of antimicrobial peptides against KPC-producing bacteria

Guilherme da Costa de Souza  1 , Cesar Augusto Roque-Borda  1 , Fernando R Pavan  1
Affiliations
Review

Beta-lactam resistance and the effectiveness of antimicrobial peptides against KPC-producing bacteria

Guilherme da Costa de Souza et al. Drug Dev Res. 2022 Nov.

Abstract

Bacterial resistance is a problem that is giving serious cause for concern because bacterial strains such as Acinetobacter baumannii and Pseudomonas aeruginosa are difficult to treat and highly opportunistic. These bacteria easily acquire resistance genes even from other species, which confers greater persistence and tolerance towards conventional antibiotics. These bacteria have the highest death rate in hospitalized intensive care patients, so strong measures must be taken. In this review, we focus on the use of antimicrobial peptides (AMPs) as an alternative to traditional drugs, due to their rapid action and lower risk of generating resistance by microorganisms. We also present an overview of beta-lactams and explicitly explain the activity of AMPs against carbapenemase-producing bacteria as potential alternative agents for infection control.

Keywords: antimicrobial peptides; antimicrobial resistance; carbapenemase.

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References

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