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. 2022 Jul 29;41(3):263-274.
doi: 10.5937/jomb0-34155.

Genetic polymorphism of matrix metalloproteinase 9 and susceptibility to chronic obstructive pulmonary disease: A meta-analysis

Xiaoping Yang  1 , Yuanyuan Yu  2 , Yong Wang  1 , Wen Jiang  1 , Wenqing Jiang  1 , Bin Yin  1
Affiliations

Genetic polymorphism of matrix metalloproteinase 9 and susceptibility to chronic obstructive pulmonary disease: A meta-analysis

Xiaoping Yang et al. J Med Biochem. .

Abstract
in English, Serbian

Background: To systematically analyze the influence of genetic polymorphisms of matrix metalloproteinase 9 (MMP9) on susceptibility to chronic obstructive pulmonary disease (COPD).

Methods: Relevant literatures reporting MMP9 and susceptibility to COPD in PubMed, Web of Science, VIP, Wanfang and CNKI databases were searched using the key words "matrix metalloproteinases 9/MMP9, COPD/chronic obstructive pulmonary disease". Data of eligible literatures were extracted and analyzed for the odds ratio (OR) and corresponding 95% CI.

Results: A total of 16 independent studies reporting MMP9-1562C/T and COPD patients were enrolled and analyzed. None of the genetic models revealed the relationship between MMP9-1562C/T and susceptibility to COPD. Subgroup analyses identified lower risk of COPD in Chinese population carrying the TT genotype for theMMP9 rs3918242 relative to those carrying CT and CC genotypes (P=0.03, OR=0.67, 95% CI=0.46-0.97).

Conclusions: Chinese population carrying the TT genotype for the MMP-9 rs3918242 present lower susceptibility to COPD relative to those carrying CT and CC genotypes.

Uvod: Sistematska analiza uticaja genetskih polimorfizama matriks metaloproteinaze 9 (MMP9) na osetljivost hronične opstruktivne bolesti pluća (HOBP).

Metode: Relevantna literatura koja izveštava o MMP9 i podložnosti HOBP u bazama podataka PubMed, Web of Scince, VIP, Wanfang i CNKI pretraživana je korišćenjem ključnih reči "matriks metaloproteinaze 9/MMP9, COPD/hronična opstruktivna bolest pluća". Podaci iz kvalifikovane literature su ekstrahovani i analizirani za odnos šanse (OR) i odgovarajući 95% CI.

Rezultati: Ukupno je uključeno i analizirano 16 nezavisnih studija koje su izveštavale o pacijentima sa MMP9-1562C/T i HOBP. Nijedan od genetskih modela nije otkrio vezu između MMP9-1562C/T i osetljivosti na HOBP. Analize podgrupa identifikovale su niži rizik od HOBP kod kineske populacije koja nosi TT genotip za MMP-9 rs3918242 u odnosu na one koji nose CT i CC genotipove (P=0,03, OR=0,67, 95% CI=0,46-0,97).

Zaključak: Kineska populacija koja nosi TT genotip za MMP9 rs3918242 predstavlja manju osetljivost na HOBP u odnosu na one sa CT i CC genotipovima.

Keywords: COPD; MMP9; meta-analysis; polymorphism.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: The authors stated that they have no conflicts of interest regarding the publication of this article.

Figures

Figure 1
Figure 1. Flow diagram of the publication selection process
Figure 2
Figure 2. Forest map of the relationship between the SNP of MMP-9 rs3918242 and susceptibility to COPD
Figure 3
Figure 3. Forest map of the relationship between the SNP of MMP-9 rs3918242 and susceptibility to COPD
Figure 4
Figure 4. Forest map of the relationship between the SNP of MMP-9 rs3918242 and susceptibility to COPD
Figure 5
Figure 5. Subgroup analyses of the relationship between the SNP of MMP-9 rs3918242 and susceptibility to COPD in different regions and different pairs of comparisons
Figure 6
Figure 6. Subgroup analyses of the relationship between the SNP of MMP-9 rs3918242 and susceptibility to COPD in different regions and different pairs of comparisons
Figure 7
Figure 7. Subgroup analyses of the relationship between the SNP of MMP-9 rs3918242 and susceptibility to COPD in Chinese population and different pairs of comparisons
Figure 8
Figure 8. Subgroup analyses of the relationship between the SNP of MMP-9 rs3918242 and susceptibility to COPD in Chinese population and different pairs of comparisons
See this image and copyright information in PMC

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