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. 2022 Sep-Oct;12(5):633-638.
doi: 10.1016/j.jobcr.2022.08.013. Epub 2022 Aug 17.

Evaluation of serum and salivary PCSK9 and IL6 and its association with periodontal inflammation and atherosclerotic cardiovascular diseases

Roshan R Rughwani  1 , Priyanka K Cholan  1 , Dhayanand John Victor  1 , Paavai Ilango  2 , Sanjay M Cherian  3 , Rajkumar N Rughwani  4 , Anupama Tadepalli  1
Affiliations

Evaluation of serum and salivary PCSK9 and IL6 and its association with periodontal inflammation and atherosclerotic cardiovascular diseases

Roshan R Rughwani et al. J Oral Biol Craniofac Res. 2022 Sep-Oct.

Erratum in

Abstract

Background: and Purpose: The aim of this study was to assess, compare and correlate the ability of PCSK9 and IL6 as potential common serum and salivary biomarkers for stage III/IV periodontitis and the risk of developing atherosclerotic cardiovascular diseases.

Methods: 76 patients were alloted into 4 groups consisting of subjects with clinically healthy periodontium and stage III/IV periodontitis with and without ACVD. Clinical parameters - PD, CAL, number of teeth, PI, mSBI, TC, Tg, HDL and LDL were recorded. Serum and saliva samples were obtained and subjected to ELISA for quantifying the biomarker levels.

Results: The level of these biomarkers was found to be the lowest (IL6 Serum: 21.92 ± 14.54, IL6 Saliva: 12.34 ± 7.72, PCSK9 Serum: 178.82 ± 35.07, PCSK9 Saliva: 80.82 ± 25.43) in group I and highest in group IV (IL6 Serum: 73.4 ± 24.86, IL6 Saliva: 37.66 ± 15.77, PCSK9 Serum: 346.54 ± 45.11, PCSK9 Saliva: 157.72 ± 43.28). The clinical parameters PI, mSBI, PPD, CAL, total number of teeth, TC, HDL and LDL showed a significant correlation with biomarkers PCSK9 and IL6.

Conclusion: This study features the elevation of serum and salivary PCSK9 and IL6 in periodontitis and ACVD. A triad of serum and salivary PCSK9 and IL6 along with the clinical markers of periodontal disease can relatively predict the future risk of developing ACVD.

Keywords: Atherosclerotic cardiovascular disease; Biomarkers; Chronic inflammation; IL6; PCSK9; Periodontal disease.

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Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
Scatter plot representing correlation between biomarkers in all groups.
Fig. 2
Fig. 2
ROC demonstrating the performance of the biomarkers.
See this image and copyright information in PMC

References

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