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. 2022 Sep 14;144(36):16332-16337.
doi: 10.1021/jacs.2c08200. Epub 2022 Aug 31.

Total Synthesis of Resiniferatoxin

Vasil H Vasilev  1 , Lukas Spessert  1 , Kuan Yu  1 , Thomas J Maimone  1
Affiliations

Total Synthesis of Resiniferatoxin

Vasil H Vasilev et al. J Am Chem Soc. .

Abstract

From both structural and functional perspectives, the large family of daphnane diterpene orthoesters (DDOs) represent a truly remarkable class of natural products. As potent lead compounds for the treatment of pain, neurodegeneration, HIV/AIDS, and cancer, their medicinal potential continues to be heavily investigated, yet synthetic routes to DDO natural products remain rare. Herein we report a distinct approach to this class of complex diterpenes, highlighted by a 15-step total synthesis of the flagship DDO, resiniferatoxin.

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