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Review
. 2022 Nov 1;25(6):401-406.
doi: 10.1097/MCO.0000000000000870. Epub 2022 Aug 31.

Collagen peptide supplementation for pain and function: is it effective?

Shiloah A Kviatkovsky  1   2   3 , Robert C Hickner  1   2   4 , Michael J Ormsbee  1   2   4
Affiliations
Review

Collagen peptide supplementation for pain and function: is it effective?

Shiloah A Kviatkovsky et al. Curr Opin Clin Nutr Metab Care. .

Abstract

Purpose of review: Connective tissue injuries are prevalent in active and aging populations, leading to chronic pain and decreased function. Turnover of this tissue is not well understood, especially as it relates to aging and injury. Supplementation of collagen peptides has been shown to improve connective tissue recovery and pain through increased collagen production.

Recent findings: Collagen peptide supplementation improves pain and function, and upregulates metabolic pathways associated with muscle and tendon growth. Literature from the past 12-18 months supports that these pathways are also involved with increased synthesis and degradation of collagen and other elements of the extracellular matrix. Improvements in body composition and strength have been noted with collagen peptide supplementation when paired with resistance training. Collagen peptide supplements are hydrolyzed into small peptides, termed bioactive peptides, and individual amino acids. These bioactive peptides are associated with the benefits observed with collagen peptide supplementation and may play a critical role in the collagen turnover.

Summary: Collagen peptide supplementation has been shown to promote recovery, decrease pain, and improve strength and body composition when paired with resistance training. These benefits may be attributed to bioactive peptides in collagen peptide supplements. Additional research is warranted to examine the specific effects of these bioactive peptides.

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References

    1. Cao C, Xiao Z, Tong H, et al. Oral intake of chicken bone collagen peptides anti-skin aging in mice by regulating collagen degradation and synthesis, inhibiting inflammation and activating lysosomes. Nutrients 2022; 14:1622.
    1. Koizumi S, Inoue N, Sugihara F, Igase M. Effects of collagen hydrolysates on human brain structure and cognitive function: a pilot clinical study. Nutrients 2020; 12:50.
    1. Kviatkovsky SA, Hickner RC, Gipson SD, et al. Collagen peptide supplementation improves measures of activities of daily living and pain in active adults. Proceedings of the Eighteenth International Society of Sports Nutrition (ISSN) Conference and Expo. 2021.
    1. Kviatkovsky SA, Hickner RC, Gipson SD, et al. Collagen peptide supplementation improves measures mental component scores of the VR-12 in active adults. Proceedings of the Nineteenth International Society of Sports Nutrition (ISSN) Conference and Expo 2022. In press.
    1. Ricard-Blum S. The collagen family. Cold Spring Harbor Perspect Biol 2011; 3:1–19.