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. 2022 Sep 8;387(10):953-954.
doi: 10.1056/NEJMc2209479. Epub 2022 Aug 31.

Risk of BA.5 Infection among Persons Exposed to Previous SARS-CoV-2 Variants

João Malato  1 , Ruy M Ribeiro  2 , Pedro P Leite  3 , Pedro Casaca  3 , Eugénia Fernandes  3 , Carlos Antunes  4 , Válter R Fonseca  3 , Manuel C Gomes  4 , Luis Graca  5
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Risk of BA.5 Infection among Persons Exposed to Previous SARS-CoV-2 Variants

João Malato et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Protective Effect of Previous SARS-CoV-2 Infection on Infection with the Omicron BA.5 Subvariant.
As shown in Panel A, we identified the periods (in different colors) when one variant was represented in more than 90% of sample isolates (data from the national severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] genetic diversity surveillance). The periods in gray represent times when more than one variant was in circulation. Given the relatively slow transition between dominance by the omicron BA.1 subvariant and dominance by the omicron BA.2 subvariant, we pooled BA.1 and BA.2 in the analysis. We did not include anyone infected in the 90 days before dominance by the omicron BA.5 subvariant. Panel B shows protection efficacy against infection during the period of BA.5 dominance (from June 1, 2022) among persons with one infection in the periods of dominance of different variants, as represented in Panel A, as compared with persons without any documented infection until June 1. Persons with two infections before June 1 were not included in the study. 𝙸 bars represent 95% confidence intervals.
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