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. 2022 Jul 16:80:104167.
doi: 10.1016/j.amsu.2022.104167. eCollection 2022 Aug.

CLI nical P rofile and S ide E ffects of chronic use of oral A miodarone in cardiology outpatients department (CLIPSE-A Study)- A prospective observational study

Nabeela Fatima  1 , Kiranmai Mandava  1 , Fatima Khatoon  1 , Juveria Badar  1 , Syeda Fatima Begum  1 , C Narasimhan  2 , K Daljeet  2 , Walli Mohammed  3
Affiliations

CLI nical P rofile and S ide E ffects of chronic use of oral A miodarone in cardiology outpatients department (CLIPSE-A Study)- A prospective observational study

Nabeela Fatima et al. Ann Med Surg (Lond). .

Abstract

Background: Amiodarone belongs to Class-III anti-arrhythmic drugs. It is one of the most effective anti-arrhythmic drugs used to treat or prevent several types of arrhythmias including atrial fibrillation, atrial flutter, ventricular tachycardia, and wide complex tachycardia, but unfortunately carries a high toxicity profile. Also, side effects of amiodarone involving various organs can be life-threatening.

Materials & methods: This was an observational study carried out for six months i.e from April to September. The study included patients who are on amiodarone for greater than or equal to six months. The required data was collected in-person from the case sheets, treatment charts, and by interviewing the patients. The data for 67 patients was documented in suitable data collection form for analysis.

Results: From our study data, it was noted that amiodarone was used for 3 different indications-atrial fibrillation, atrial flutter, and ventricular tachycardia. Among 67 patients enrolled, 38 had no side-effects. Side-effects data in the rest grouped basing on the organ system affected: 9 patients had renal effects, 6 patients had ophthalmic effects, 4 patients had endocrine effects, and 5 patients had hepatic effects.

Conclusion: From our study, it is concluded that amiodarone is a safe and effective anti-arrhythmic drug at lower doses i.e. 200-1100 mg/week. When treated in lower doses of 1400-2800 mg/week, many side effects have been incident. Although these effects are mild and develop only after prolonged usage of the drug, it should be used judiciously.

Keywords: AF, Atrial fibrillation; AIH, Amiodarone induced hypothyroidism; AIT, Amiodarone induced thyrotoxicosis; AV, Atrioventricular; Amiodarone; Atrial fibrillation; Atrial flutter; BMI, Body mass index; CPR, Cardiopulmonary resuscitation; DEA, Des ethyl amiodarone; FDA, Food and drug administration; INR, International normalized ratio; PSVT, Paraoxysmal supraventricular tachycardia; Paroxysmal atrial fibrillation; SGOT, Serum glutamic-oxaloacetic transaminase; SGPT, Serum glutamic pyruvic transaminase; Side-effects; VF, Ventricular Fibrillation; VT, Ventricular tachycardia; Ventricular tachycardia.

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Figures

Figure-1
Figure-1
Mechanism of action of amiodarone (Adapted from Osmosis.org [6]).
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Fig. 2
Side-Effects of amiodarone.
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Fig. 3
Study methodology.
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Fig. 4
Gender prevalence.
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Medical history of diseases.
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Indications of amiodarone.
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Weekly dose for patients.
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Fig. 8
Eye Examination data.
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Fig. 9
Side effects.
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Fig. 10
Dose and Side-effect correlation.
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