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Comment
. 2022 Sep 1;107(9):2009-2010.
doi: 10.3324/haematol.2022.281711.

The beginnings of molecular medicine

Affiliations
Comment

The beginnings of molecular medicine

David C Rees. Haematologica. .
No abstract available

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Figures

Figure 1.
Figure 1.
Rates of globin synthesis in reticulocytes from a patient with b-thalassemia major. Incorporation of radioactivity into globin chains after reticulocytes from a patient with b-thalassemia major had been incubated for 60 minutes with 14C-leucine. The solid line shows the amount of total protein, which is approximately the same for both b and a globin chains. The dotted line shows the rate of synthesis of new globin chains over the 60 minutes of the incubation, with significantly less synthesis of b globin compared to a globin.

Comment on

References

    1. Cooley TB, Lee P. A series of cases of splenomegaly in children with anemia and peculiar bone changes. Trans Am Pediatr Soc. 1925;37:29-30.
    1. Weatherall DJ, Clegg JB, Naughton MA. Globin synthesis in thalassaemia: an in vitro study. Nature. 1965;208(5015):1061-1065. - PubMed
    1. Fairweather DV, Modell B, Berdoukas V, et al. . Antenatal diagnosis of thalassaemia major. Br Med J. 1978;1(6109):350-353. - PMC - PubMed